Effects of soman on calcium influx into rabbit aorta

The acute addition of 10 μM soman to rabbit aorta rings did not increase resting 45Ca 2+ influx significantly in the absence or presence of 10 μM norepinephrine or 80 mM potassium ( P >; 0.05). However, agonist-induced 45Ca 2+ influx into aorta rings from rabbits that received soman daily for 7 d...

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Veröffentlicht in:	Toxicology letters 1990-11, Vol.54 (1), p.33-37
Hauptverfasser:	Hsu, Chia-Hsuh, Hu, Chao-Yu, Robinson, Casey P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta - drug effects Aorta - metabolism Biological and medical sciences Calcium - metabolism Chemical and industrial products toxicology. Toxic occupational diseases Drug Interactions Medical sciences Muscle Contraction - drug effects Muscle, Smooth, Vascular - drug effects Norepinephrine - pharmacology Potassium - pharmacology Rabbits Soman - pharmacology Soman in rabbit aorta Soman on calcium uptake Toxicology Various organic compounds
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Zusammenfassung:	The acute addition of 10 μM soman to rabbit aorta rings did not increase resting 45Ca 2+ influx significantly in the absence or presence of 10 μM norepinephrine or 80 mM potassium ( P >; 0.05). However, agonist-induced 45Ca 2+ influx into aorta rings from rabbits that received soman daily for 7 days was significantly reduced ( P < 0.05) compared to agonist-induced influx into rings from control rabbits. The resting influx of 45Ca 2+ into aorta rings from 7 day soman-treated and control rabbits was not different ( P >; 0.05). The depression by soman of norepinephrine- and K +-induced 45Ca 2+ influx may be due to adaptive changes resulting from the 7-day administration of soman.
ISSN:	0378-4274 1879-3169
DOI:	10.1016/0378-4274(90)90052-N