Failure of Pretreatment With Intravenous Folic Acid to Alter the Cumulative Hematologic Toxicity of Lometrexol

Failure of Pretreatment With Intravenous Folic Acid to Alter the Cumulative Hematologic Toxicity of Lometrexol

In a study, 5 mg folic acid was given intravenously one hour before lometrexol every three weeks. The failure of pretreatment with intravenous folic acid to alter the cumulative hematologic toxicity of lometrexol is discussed.

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Veröffentlicht in:JNCI : Journal of the National Cancer Institute 1996-10, Vol.88 (20), p.1495-1496
Hauptverfasser: MUGGIA, FRANCO M., SYNOLD, TIMOTHY W., NEWMAN, EDWARD M., JEFFERS, SUSAN, LEICHMAN, LAWRENCE P., DOROSHOW, JAMES H., JOHNSON, KAY, GROSHEN, SUSAN
Format: Artikel
Sprache:eng
Schlagworte:
Antimetabolites, Antineoplastic - adverse effects
Antimetabolites, Antineoplastic - pharmacokinetics
Cancer
Drug Administration Schedule
Female
Folic Acid - administration & dosage
Folic Acid - therapeutic use
Folic Acid Antagonists - adverse effects
Folic Acid Antagonists - pharmacokinetics
Humans
Infusions, Intravenous
Male
Neoplasms - drug therapy
Pancytopenia - chemically induced
Pancytopenia - prevention & control
Prescription drugs
Stomatitis - chemically induced
Stomatitis - prevention & control
Tetrahydrofolates - adverse effects
Tetrahydrofolates - pharmacokinetics
Treatment Failure
Tumors
Vitamin B
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Beschreibung
Zusammenfassung:In a study, 5 mg folic acid was given intravenously one hour before lometrexol every three weeks. The failure of pretreatment with intravenous folic acid to alter the cumulative hematologic toxicity of lometrexol is discussed.
ISSN:0027-8874
1460-2105
DOI:10.1093/jnci/88.20.1495