Extraction and Quantitation of Digoxin and Acetyldigoxin from the Digitalis lanata Leaf via Near-Supercritical Methanol-Modified Carbon Dioxide

An extraction process is reported that employs a near-supercritical mixture of CO2 and MeOH to extract the cardiac glycoside, digoxin, from the Digitalis lanata leaf. The method development of the sample preparation procedure is presented in detail, and reasons for trends that occur in the natural p...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 1996-07, Vol.59 (7), p.690-693
Hauptverfasser:	Moore, W. N, Taylor, L. T
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetyldigoxins - analysis Acetyldigoxins - isolation & purification ANALISIS CUANTITATIVO ANALYSE QUANTITATIVE Analysis Biological and medical sciences CARBON DIOXIDE CHEMICAL COMPOSITION CHEMICAL STRUCTURE Chromatography, High Pressure Liquid COMPOSICION QUIMICA COMPOSITION CHIMIQUE DERIVATIVES DIGITALIS Digitalis - chemistry Digitalis lanata Digoxin - analysis Digoxin - isolation & purification DIOXIDO DE CARBONO DIOXYDE DE CARBONE DRUG PLANTS ESPECTROMETRIA ESTEROIDES ESTRUCTURA QUIMICA FEUILLE General pharmacology HOJAS Hydrolysis ISOLATION TECHNIQUES LEAVES Medical sciences METANOL METHANOL METHODE METHODOLOGY METHODS METODOS NETHERLANDS PAISES BAJOS PAYS BAS Pharmacology. Drug treatments Plant Extracts - analysis Plant Leaves - chemistry PLANTAS MEDICINALES PLANTE MEDICINALE Plants, Medicinal Plants, Toxic QUANTITATIVE ANALYSIS SPECTRAL ANALYSIS SPECTROMETRIE SPECTROMETRY STEROIDE STEROIDS STRUCTURE CHIMIQUE TECHNIQUE DE L'ISOLEMENT TECNICAS DE AISLAMIENTO TEMPERATURA TEMPERATURE
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Beschreibung
Zusammenfassung:	An extraction process is reported that employs a near-supercritical mixture of CO2 and MeOH to extract the cardiac glycoside, digoxin, from the Digitalis lanata leaf. The method development of the sample preparation procedure is presented in detail, and reasons for trends that occur in the natural products extraction are given.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np960432g