Effects of chronic infusion of nerve growth factor (NGF) in AF64A-lesioned rats

We report here the behavioral and biochemical recovery induced by the nerve growth factor (NGF) administration in AF64A-treated rats. Retention in the passive avoidance test was affected by lesion but it was significantly improved after the NGF treatment. Similar results were observed in the perform...

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Veröffentlicht in:	Molecular and chemical neuropathology 1996-05, Vol.28 (1-3), p.175-179
Hauptverfasser:	Fernández, C I, González, O, Soto, J, Alvarez, L, Quijano, Z
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Avoidance Learning - drug effects Aziridines - toxicity Brain - drug effects Brain - pathology Brain - physiology Cerebral Cortex - enzymology Choline - analogs & derivatives Choline - toxicity Choline O-Acetyltransferase - metabolism Cognition - drug effects Cognition Disorders - chemically induced Cognition Disorders - drug therapy Cognition Disorders - psychology Corpus Striatum - enzymology Hippocampus - enzymology Infusions, Intravenous Male Maze Learning - drug effects Nerve Growth Factors - administration & dosage Nerve Growth Factors - therapeutic use Neuromuscular Blocking Agents - toxicity Rats Rats, Sprague-Dawley Time Factors
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Zusammenfassung:	We report here the behavioral and biochemical recovery induced by the nerve growth factor (NGF) administration in AF64A-treated rats. Retention in the passive avoidance test was affected by lesion but it was significantly improved after the NGF treatment. Similar results were observed in the performance during the Morris water maze (MWM) task. Remarkable losses in the ChAT activity were detected in some brain regions from lesioned rats. The NGF-induced alleviation of choline acetyltransferase (ChAT) activity losses and cognitive functions suggest a trophic and protective action on the remaining cholinergic neurons after the lesion. Thus NGF therapy could be considered as a possibility mainly in the early course of Alzheimer disease.
ISSN:	1044-7393
DOI:	10.1007/bf02815219