Histological evidence for cholinergic alteration in the hippocampus following entorhinal cortex lesion

The initial stage of Alzheimer's disease is characterized by neuropathological alteration in the entorhinal cortex. To model one aspect of the neurodegeneration observed and to investigate anatomical changes of the hippocampus associated with unilateral entorhinal cortex lesion, excitotoxin ibo...

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Veröffentlicht in:Journal of the neurological sciences 1996-10, Vol.142 (1-2), p.7-11
Hauptverfasser: UEKI, A, MIWA, C, OOHARA, K, MIYOSHI, K
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container_title Journal of the neurological sciences
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creator UEKI, A
MIWA, C
OOHARA, K
MIYOSHI, K
description The initial stage of Alzheimer's disease is characterized by neuropathological alteration in the entorhinal cortex. To model one aspect of the neurodegeneration observed and to investigate anatomical changes of the hippocampus associated with unilateral entorhinal cortex lesion, excitotoxin ibotenic acid was used to produce selective unilateral neuronal loss in rat entorhinal cortex. Histological and morphometrical analyses confirmed excitotoxic lesion of the entorhinal cortex after 3 months and showed a decrease of acetylcholineste-rase-stained fibers in the stratum moleculare of the dentate gyrus and the stratum radiatum of the CA3 field. This study demonstrates the importance of the entorhinal cortex in the hippocampal cholinergic function which appears to be important to memory and learning, and raises the possibility that memory deficit in Alzheimer's disease may be associated with partial neuronal loss in the entorhinal cortex.
doi_str_mv 10.1016/0022-510X(96)00113-X
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subjects Acetylcholinesterase - analysis
Animals
Biological and medical sciences
Cholinergic Fibers - enzymology
Cholinergic Fibers - pathology
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Dentate Gyrus - pathology
Entorhinal Cortex - pathology
Ibotenic Acid
Male
Medical sciences
Nervous System Diseases - chemically induced
Nervous System Diseases - pathology
Neurology
Rats
Rats, Wistar
title Histological evidence for cholinergic alteration in the hippocampus following entorhinal cortex lesion
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