Histological evidence for cholinergic alteration in the hippocampus following entorhinal cortex lesion
The initial stage of Alzheimer's disease is characterized by neuropathological alteration in the entorhinal cortex. To model one aspect of the neurodegeneration observed and to investigate anatomical changes of the hippocampus associated with unilateral entorhinal cortex lesion, excitotoxin ibo...
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Veröffentlicht in: | Journal of the neurological sciences 1996-10, Vol.142 (1-2), p.7-11 |
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creator | UEKI, A MIWA, C OOHARA, K MIYOSHI, K |
description | The initial stage of Alzheimer's disease is characterized by neuropathological alteration in the entorhinal cortex. To model one aspect of the neurodegeneration observed and to investigate anatomical changes of the hippocampus associated with unilateral entorhinal cortex lesion, excitotoxin ibotenic acid was used to produce selective unilateral neuronal loss in rat entorhinal cortex. Histological and morphometrical analyses confirmed excitotoxic lesion of the entorhinal cortex after 3 months and showed a decrease of acetylcholineste-rase-stained fibers in the stratum moleculare of the dentate gyrus and the stratum radiatum of the CA3 field. This study demonstrates the importance of the entorhinal cortex in the hippocampal cholinergic function which appears to be important to memory and learning, and raises the possibility that memory deficit in Alzheimer's disease may be associated with partial neuronal loss in the entorhinal cortex. |
doi_str_mv | 10.1016/0022-510X(96)00113-X |
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To model one aspect of the neurodegeneration observed and to investigate anatomical changes of the hippocampus associated with unilateral entorhinal cortex lesion, excitotoxin ibotenic acid was used to produce selective unilateral neuronal loss in rat entorhinal cortex. Histological and morphometrical analyses confirmed excitotoxic lesion of the entorhinal cortex after 3 months and showed a decrease of acetylcholineste-rase-stained fibers in the stratum moleculare of the dentate gyrus and the stratum radiatum of the CA3 field. This study demonstrates the importance of the entorhinal cortex in the hippocampal cholinergic function which appears to be important to memory and learning, and raises the possibility that memory deficit in Alzheimer's disease may be associated with partial neuronal loss in the entorhinal cortex.</description><subject>Acetylcholinesterase - analysis</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cholinergic Fibers - enzymology</subject><subject>Cholinergic Fibers - pathology</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Dentate Gyrus - pathology</subject><subject>Entorhinal Cortex - pathology</subject><subject>Ibotenic Acid</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nervous System Diseases - chemically induced</subject><subject>Nervous System Diseases - pathology</subject><subject>Neurology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><issn>0022-510X</issn><issn>1878-5883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE9rGzEQxUVJSZy036ABHUJJD9uOpNWfPYbQxIVALw34JrSy1laQpY202ybfvjI2Pg3D-73HzEPoC4HvBIj4AUBpwwmsbjvxDYAQ1qw-oAVRUjVcKXaGFifkAl2W8gIAQqnuHJ2rDqgkdIGGpS9TCmnjrQnY_fVrF63DQ8rYblPw0eUqYRMml83kU8Q-4mnr8NaPY7JmN86l0iGkfz5usItTylsfa5ZNeXJvOLhSXZ_Qx8GE4j4f5xV6fvj5537ZPP1-_HV_99RYJujUcFq_sJ2xdugNWC4Yt2B7xpSQAkAC4XWhihomJQPWmrXtnOGM930La86u0NdD7pjT6-zKpHe-WBeCiS7NRRMuJfBWVrA9gDanUrIb9Jj9zuR3TUDv69X77vS-O93tl3qYXlXb9TF_7ndufTId-6z6zVE3pRY6ZBOtLyeMUd4KIdh_uFCEIw</recordid><startdate>19961001</startdate><enddate>19961001</enddate><creator>UEKI, A</creator><creator>MIWA, C</creator><creator>OOHARA, K</creator><creator>MIYOSHI, K</creator><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>19961001</creationdate><title>Histological evidence for cholinergic alteration in the hippocampus following entorhinal cortex lesion</title><author>UEKI, A ; MIWA, C ; OOHARA, K ; MIYOSHI, K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c362t-52113c9accfba0c5635c0cb338676007015b33282a3773034adc9ea535bb40d53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Acetylcholinesterase - analysis</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cholinergic Fibers - enzymology</topic><topic>Cholinergic Fibers - pathology</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Dentate Gyrus - pathology</topic><topic>Entorhinal Cortex - pathology</topic><topic>Ibotenic Acid</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nervous System Diseases - chemically induced</topic><topic>Nervous System Diseases - pathology</topic><topic>Neurology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>UEKI, A</creatorcontrib><creatorcontrib>MIWA, C</creatorcontrib><creatorcontrib>OOHARA, K</creatorcontrib><creatorcontrib>MIYOSHI, K</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>Journal of the neurological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>UEKI, A</au><au>MIWA, C</au><au>OOHARA, K</au><au>MIYOSHI, K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Histological evidence for cholinergic alteration in the hippocampus following entorhinal cortex lesion</atitle><jtitle>Journal of the neurological sciences</jtitle><addtitle>J Neurol Sci</addtitle><date>1996-10-01</date><risdate>1996</risdate><volume>142</volume><issue>1-2</issue><spage>7</spage><epage>11</epage><pages>7-11</pages><issn>0022-510X</issn><eissn>1878-5883</eissn><coden>JNSCAG</coden><abstract>The initial stage of Alzheimer's disease is characterized by neuropathological alteration in the entorhinal cortex. To model one aspect of the neurodegeneration observed and to investigate anatomical changes of the hippocampus associated with unilateral entorhinal cortex lesion, excitotoxin ibotenic acid was used to produce selective unilateral neuronal loss in rat entorhinal cortex. Histological and morphometrical analyses confirmed excitotoxic lesion of the entorhinal cortex after 3 months and showed a decrease of acetylcholineste-rase-stained fibers in the stratum moleculare of the dentate gyrus and the stratum radiatum of the CA3 field. This study demonstrates the importance of the entorhinal cortex in the hippocampal cholinergic function which appears to be important to memory and learning, and raises the possibility that memory deficit in Alzheimer's disease may be associated with partial neuronal loss in the entorhinal cortex.</abstract><cop>Shannon</cop><pub>Elsevier Science</pub><pmid>8902712</pmid><doi>10.1016/0022-510X(96)00113-X</doi><tpages>5</tpages></addata></record> |
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subjects | Acetylcholinesterase - analysis Animals Biological and medical sciences Cholinergic Fibers - enzymology Cholinergic Fibers - pathology Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dentate Gyrus - pathology Entorhinal Cortex - pathology Ibotenic Acid Male Medical sciences Nervous System Diseases - chemically induced Nervous System Diseases - pathology Neurology Rats Rats, Wistar |
title | Histological evidence for cholinergic alteration in the hippocampus following entorhinal cortex lesion |
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