Effect of catecholaminergic drugs on quinolinate- and kynurenine-induced seizures in mice

The data obtained suggest a similarity of kynurenine and known convulsants in the involvement of the catecholaminergic processes in their convulsant action. Quinolinic acid markedly differs from kynurenine in its mechanism of action as indicated by their interactions with numerous endogenous substan...

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Veröffentlicht in:	Journal of Neural Transmission 1990-02, Vol.82 (1), p.55-65
Hauptverfasser:	LAPIN, I. P, RYZOV, I. V
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Drug toxicity and drugs side effects treatment Medical sciences Pharmacology. Drug treatments Toxicity: nervous system and muscle
Online-Zugang:	Volltext
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Zusammenfassung:	The data obtained suggest a similarity of kynurenine and known convulsants in the involvement of the catecholaminergic processes in their convulsant action. Quinolinic acid markedly differs from kynurenine in its mechanism of action as indicated by their interactions with numerous endogenous substances.
ISSN:	0300-9564 1435-1463
DOI:	10.1007/BF01244834