Anti-Candida Activity and Toxicology of LY121019, a Novel Semisynthetic Polypeptide Antifungal Antibiotic

We will review the in vitro anti-Candida activity of LY121019 and the effectiveness of this novel antifungal antibiotic against experimental Candida infections. We will discuss the mode of action of LY121019 based on previous observations that LY121019 caused severe damage to the Candida cell wall a...

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Veröffentlicht in:	Annals of the New York Academy of Sciences 1988, Vol.544 (1), p.294-309
Hauptverfasser:	GORDEE, ROBERT S., ZECKNER, DOUGLAS J., HOWARD, LEONARD C., ALBORN JR, WILLIAM E., DEBONO, MANUEL
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antifungal Agents - pharmacology Candida Candida - drug effects Candida - growth & development Candida albicans - drug effects Candida albicans - growth & development Echinocandins Mice Microbial Sensitivity Tests Peptides - pharmacology Peptides - toxicity Peptides, Cyclic Species Specificity
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Zusammenfassung:	We will review the in vitro anti-Candida activity of LY121019 and the effectiveness of this novel antifungal antibiotic against experimental Candida infections. We will discuss the mode of action of LY121019 based on previous observations that LY121019 caused severe damage to the Candida cell wall and summarize results of toxicological studies of LY121019.
ISSN:	0077-8923 1749-6632
DOI:	10.1111/j.1749-6632.1988.tb40415.x