Effects of S-adenosyl- l-methionine on phospholipid methyltransferase activity changes induced by thioacetamide

In this paper we have studied the role of phospholipid methyl-transferase in (thioacetamide) (TAA)-induced liver necrosis and the effect of exogenous administration of (S-adenosyl-L-methionine) (Ado-met) on this activity.

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Bibliographische Detailangaben
Veröffentlicht in:	Biochemical pharmacology 1990-08, Vol.40 (3), p.648-651
Hauptverfasser:	Osada, Jesus, Aylagas, Hortensia, Palacios-Alaiz, Evangelina
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetamides - pharmacology Animals liver Liver - drug effects Liver - pathology Male Methyltransferases - metabolism Microsomes, Liver - drug effects Microsomes, Liver - enzymology Necrosis Phosphatidyl-N-Methylethanolamine N-Methyltransferase Phosphatidylcholines - metabolism Phosphatidylethanolamine N-Methyltransferase Phosphatidylethanolamines - metabolism phospholipid methyltransferase Rats Rats, Inbred Strains S-adenosylmethionine S-Adenosylmethionine - pharmacology Thioacetamide - pharmacology Thioacetamide - toxicity
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Beschreibung
Zusammenfassung:	In this paper we have studied the role of phospholipid methyl-transferase in (thioacetamide) (TAA)-induced liver necrosis and the effect of exogenous administration of (S-adenosyl-L-methionine) (Ado-met) on this activity.
ISSN:	0006-2952 1873-2968
DOI:	10.1016/0006-2952(90)90569-7