Relationship between intracellular pH and ammonia metabolism in LLC-PK sub(1) cells

Relationship between intracellular pH and ammonia metabolism in LLC-PK sub(1) cells

Previous studies from our laboratory have confirmed that cultures of LLC-PK sub(1) cells exhibit pH-responsive alterations in ammonia metabolism produced by changes in media bicarbonate concentration. To further elucidate the mechanism of ammonia regulation, studies were carried out using parallel c...

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Veröffentlicht in:American Journal of Physiology: Cell Physiology 1990-01, Vol.258 (1), p.F103-F108
Hauptverfasser: Sahali, A, Laughrey, E, Tannen, R L
Format: Artikel
Sprache:eng
Schlagworte:
ammonia
kidney
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Zusammenfassung:Previous studies from our laboratory have confirmed that cultures of LLC-PK sub(1) cells exhibit pH-responsive alterations in ammonia metabolism produced by changes in media bicarbonate concentration. To further elucidate the mechanism of ammonia regulation, studies were carried out using parallel cultures of still and rocked LLC-PK sub(1) cells subjected to acute alterations in media pH by either metabolic or respiratory acid-based manipulations.
ISSN:0363-6143