The reovirus nonstructural protein sigma 1NS is recognized by murine cytotoxic T lymphocytes

The reovirus nonstructural protein sigma 1NS is recognized by murine cytotoxic T lymphocytes

The cytotoxic T-lymphocyte (CTL) response in reovirus-infected C3H mice was investigated by using reovirus-vaccinia virus recombinants. Results of cytotoxicity assays indicated that the nonstructural protein sigma 1NS elicited a significant CTL response. Experiments with sigma 1NS-specific CTL lines...

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Veröffentlicht in:Journal of virology 1996-11, Vol.70 (11), p.8160-8164
Hauptverfasser: Hoffman, L M, Hogan, K T, Cashdollar, L W
Format: Artikel
Sprache:eng
Schlagworte:
rotavirus
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Zusammenfassung:The cytotoxic T-lymphocyte (CTL) response in reovirus-infected C3H mice was investigated by using reovirus-vaccinia virus recombinants. Results of cytotoxicity assays indicated that the nonstructural protein sigma 1NS elicited a significant CTL response. Experiments with sigma 1NS-specific CTL lines showed that both strain-specific and cross-reactive epitopes exist in the sigma 1NS protein.
ISSN:0022-538X
DOI:10.1128/JVI.70.11.8160-8164.1996