The timing of aromatic deoxygenation in aflatoxin biosynthesis

Deoxygenation of phenols is a difficult reaction to execute synthetically. Yet among polyketide-derived natural products many instances can be found where such reactions appear to occur in the course of their biosynthesis. Deoxygenation of versicolorin A could occur at C-6 to provide a necessary red...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of the American Chemical Society 1989-10, Vol.111 (21), p.8306-8308
Hauptverfasser:	Graybill, Todd L, Pal, Kollol, McGuire, Sean M, Brobst, Susan W, Townsend, Craig A
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Fundamental and applied biological sciences. Psychology Microbiology Mycology Pathogenicity, host-agent relations, miscellaneous strains, epidemiology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Deoxygenation of phenols is a difficult reaction to execute synthetically. Yet among polyketide-derived natural products many instances can be found where such reactions appear to occur in the course of their biosynthesis. Deoxygenation of versicolorin A could occur at C-6 to provide a necessary reduction in the course of its conversion to sterigmatocystin, a late intermediate in aflatoxin B sub(1) biosynthesis.
ISSN:	0002-7863 1520-5126
DOI:	10.1021/ja00203a057