Generation of tumoricidal effector cells with a novel potentiator: N-(4-((4-fluorophenyl)-sulfonyl)phenyl) acetamide (CL 259,763)

An effort was made to investigate the effects of a novel immunopotentiator, N-(4-((4-fluorophenyl)-sulfonyl)-phenyl) acetamide (CL 259,763), on the generation of tumoricidal effector cells. CL 259,763 is an orally active immunomodulator capable of inducing tumor inhibitory macrophages and potentiating CTL responses to syngeneic tumor cells and, therefore, may prove clinically useful in the treatment of neoplastic diseases.