Antimalarial sesquiterpenes from tubers of Cyperus rotundus: structure of 10,12-Peroxycalamenene, a sesquiterpene endoperoxide

Activity-guided investigation of Cyperus rotundus tubers led to the isolation of patchoulenone, caryophyllene α-oxide, 10,12-peroxycalamenene and 4,7-dimethyl-1-tetralone. The antimalarial activities of these compounds are in the range of EC 50 10 −4–10 −6 M, with the novel endoperoxide sesquiterpen...

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Veröffentlicht in:	Phytochemistry (Oxford) 1995-09, Vol.40 (1), p.125-128
Hauptverfasser:	Thebtaranonth, C., Thebtaranonth, Y., Wanauppathamkul, S., Yuthavong, Y.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antimalarials - chemistry Antimalarials - isolation & purification Antimalarials - toxicity Biological and medical sciences Chemical constitution Cyperus rotundus Fundamental and applied biological sciences. Psychology General pharmacology Magnetic Resonance Spectroscopy Medical sciences Molecular Structure Optical Rotation Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant physiology and development Plant Roots Plants, Medicinal Plasmodium falciparum Plasmodium falciparum - drug effects Sesquiterpenes - chemistry Sesquiterpenes - isolation & purification Sesquiterpenes - toxicity
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Beschreibung
Zusammenfassung:	Activity-guided investigation of Cyperus rotundus tubers led to the isolation of patchoulenone, caryophyllene α-oxide, 10,12-peroxycalamenene and 4,7-dimethyl-1-tetralone. The antimalarial activities of these compounds are in the range of EC 50 10 −4–10 −6 M, with the novel endoperoxide sesquiterpene, 10,12-peroxycalamenene, exhibiting the strongest effect at EC 50 2.33 × 10 −6 M.
ISSN:	0031-9422 1873-3700
DOI:	10.1016/0031-9422(95)00260-E