Microbial Transformation of Artemether

Microbial transformation of the semisynthetic sesquiterpene artemether, using Cunninghamella elegans and Streptomyces lavendulae, resulted in the isolation of five microbial metabolites that were characterized on the basis of their 1H and 13C NMR spectral data. These metabolites were identified as 9...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 1996-01, Vol.59 (3), p.251-253
Hauptverfasser:	Abourashed, Ehab A, Hufford, Charles D
Format:	Artikel
Sprache:	eng
Schlagworte:	Alicyclic compounds, terpenoids, prostaglandins, steroids analogs Antibiotics. Antiinfectious agents. Antiparasitic agents antimalarials Antiparasitic agents Artemisia annua artemisinin biodegradation Biological and medical sciences chemical structure Chemistry Cunninghamella elegans derivatives Exact sciences and technology Medical sciences metabolites molecular conformation Organic chemistry Pharmacology. Drug treatments Preparations and properties Streptomyces lavendulae Terpenoids
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Beschreibung
Zusammenfassung:	Microbial transformation of the semisynthetic sesquiterpene artemether, using Cunninghamella elegans and Streptomyces lavendulae, resulted in the isolation of five microbial metabolites that were characterized on the basis of their 1H and 13C NMR spectral data. These metabolites were identified as 9β-hydroxyartemether, 9α-hydroxyartemether, ring-rearranged 9β-hydroxyartemether, 3α-hydroxydeoxyartemether, and 14-hydroxyartemether. The latter three compounds are new and are being reported here for the first time.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np960060b