Suppression of TNF-α-Induced Apoptosis by NF-κB

Tumor necrosis factor α (TNF-α) signaling gives rise to a number of events, including activation of transcription factor NF-κB and programmed cell death (apoptosis). Previous studies of TNF-α signaling have suggested that these two events occur independently. The sensitivity and kinetics of TNF-α-in...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 1996-11, Vol.274 (5288), p.787-789
Hauptverfasser: Van Antwerp, Daniel J., Martin, Seamus J., Kafri, Tal, Green, Douglas R., Verma, Inder M.
Format: Artikel
Sprache:eng
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Zusammenfassung:Tumor necrosis factor α (TNF-α) signaling gives rise to a number of events, including activation of transcription factor NF-κB and programmed cell death (apoptosis). Previous studies of TNF-α signaling have suggested that these two events occur independently. The sensitivity and kinetics of TNF-α-induced apoptosis are shown to be enhanced in a number of cell types expressing a dominant-negative IκBα (IκBαM). These findings suggest that a negative feedback mechanism results from TNF-α signaling in which NF-κB activation suppresses the signals for cell death.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.274.5288.787