Influence of Epilobium angustifolium extract on 5α-reductase type 2 and MAPK3 kinase gene expression in rats prostates

The aim of this study was to investigate the influence of standardized Epilobium angustifolium L. extract [100 mg/kg/day, p.o.] on the expression level of 5α-reductase type 2 (Srd5ar2) mRNA and Mapk3 mRNA a representative of non-genomic xenobiotics signaling pathway. It was shown that plant extract...

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Veröffentlicht in:	Herba polonica 2013-12, Vol.59 (4), p.72-85
Hauptverfasser:	Kujawski, Radosław, Bartkowiak-Wieczorek, Joanna, Karasiewicz, Monika, Bogacz, Anna, Mikołajczak, Przemysław Ł., Czerny, Bogusław, Mrozikiewicz, Przemysław M.
Format:	Artikel
Sprache:	eng
Schlagworte:	androgen receptor non-genomics signaling pathway BPH ekspresja genów Epilobium angustifolium gene expression hormonally-induced prostate hyperplasia indukowany hormonalnie rozrost prostaty niegenomowy szlak sygnalizcji wewnątrzkomórkowej zależnej od receptora androgenowego rats szczury
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Zusammenfassung:	The aim of this study was to investigate the influence of standardized Epilobium angustifolium L. extract [100 mg/kg/day, p.o.] on the expression level of 5α-reductase type 2 (Srd5ar2) mRNA and Mapk3 mRNA a representative of non-genomic xenobiotics signaling pathway. It was shown that plant extract from the E. angustifolium showed a slight tendency to reduce prostate weight in hormonally induced animals (p>0.05) and in testosterone induced animals receiving both, extract and finasteride (p
ISSN:	0018-0599 2449-8343 0018-0599
DOI:	10.2478/hepo-2013-0025