Structural and energetic analysis of drug inhibition of the influenza A M2 proton channel

Highlights • Stable drug binding in the channel pore inhibits the influenza A M2 channel. • Mutations in M2 perturb drug binding stability. • Structural biology and molecular simulations guide drug design for mutant M2 channels. • The M2 pore-binding site can bind to inhibitors of varying sizes....

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Trends in pharmacological sciences (Regular ed.) 2013-10, Vol.34 (10), p.571-580
Hauptverfasser:	Gu, Ruo-Xu, Liu, Limin Angela, Wei, Dong-Qing
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Amino Acid Sequence Antiviral Agents - chemistry Antiviral Agents - pharmacology Influenza A virus - chemistry Influenza A virus - metabolism Influenza virus Models, Molecular Molecular Sequence Data Viral Matrix Proteins - antagonists & inhibitors Viral Matrix Proteins - chemistry Viral Matrix Proteins - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights • Stable drug binding in the channel pore inhibits the influenza A M2 channel. • Mutations in M2 perturb drug binding stability. • Structural biology and molecular simulations guide drug design for mutant M2 channels. • The M2 pore-binding site can bind to inhibitors of varying sizes.
ISSN:	0165-6147 1873-3735
DOI:	10.1016/j.tips.2013.08.003