Screening Of Antimicrobial Activity Of Sesquterpenoid Crude Extract Of Ganoderma

Antimicrobial activities of sesquiterpenoid of Ganoderma were tested against human pathogenic microorganisms. Four out of 11 species of Ganoderma showed good antimicrobial activity. Minimal inhibitory concentration was determined for the sesquterpenoid extract of Ganoderma Mazandaran Ganoderma lipsiense, Ganoderma multicornum and Ganoderma lucidum on selected microorganisms. Proteus mirabilis (MTCC 1429) Candida albicans (MTCC 1637), Klebsiella pneumonia (MTCC 432), Escherichia coli (MTCC 2064) and bacillus subtilus (NCIM 2010) were tested. Ganoderma lucidum extract showed maximal inhibition of Proteus mirabilis and was also active against Candida albicans, as was the extract of Ganoderma mazandaran. Lowest MIC values were 128 l/ ml demonstrated by sesquterpenoid extract of G. lucidium, and G. Mazandaran against B. subtilus and P. mirabilis. Further separation of the sesquterpenoid compounds need to be carried out to detect the bioactivity of specific compounds.