Deformable nature of various damaged DNA duplexes estimated by an electrochemical analysis on electrodes

Deformable nature of various damaged DNA duplexes estimated by an electrochemical analysis on electrodes

We report bending flexibility of damaged duplexes possessing an apurinic/apyrimidinic (AP) site analogue, a cyclobutane pyrimidine dimer (CPD), and a pyrimidine(6-4)pyrimidone photoproduct (6-4PP). Based on the electrochemical evaluation on electrodes, the duplex flexibilities of the lesions increas...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2014-01, Vol.50 (76), p.11126-11128
Hauptverfasser: Chiba, J, Aoki, S, Yamamoto, J, Iwai, S, Inouye, M
Format: Artikel
Sprache:eng
Schlagworte:
DNA - chemistry
DNA Damage
Electrochemical Techniques
Electrodes
Molecular Structure
Pyrimidines - chemistry
Surface Properties
Ultraviolet Rays
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Zusammenfassung:We report bending flexibility of damaged duplexes possessing an apurinic/apyrimidinic (AP) site analogue, a cyclobutane pyrimidine dimer (CPD), and a pyrimidine(6-4)pyrimidone photoproduct (6-4PP). Based on the electrochemical evaluation on electrodes, the duplex flexibilities of the lesions increased in the following order: CPD < AP < 6-4PP. We discussed the possibility that the emerging local flexibility might be a good sign for UV-damaged DNA-binding proteins on duplexes.
ISSN:1359-7345
1364-548X
DOI:10.1039/c4cc04513k