Efficacy and Safety of Ecabet Sodium as an Adjuvant Therapy for Helicobacter pylori Eradication: A Systematic Review and Meta-Analysis

Background Several studies have reported that the application of ecabet sodium during the eradication of Helicobacter pylori can improve the eradication rate and reduce therapy‐associated side effects. However, the efficacy and safety of this therapy are controversial. Objectives To determine whether ecabet sodium improves the eradication rate of H. pylori and examine treatment safety by conducting a meta‐analysis based on randomized controlled trials (RCTs). Methods Literature searches were conducted in the following databases: PubMed, Embase, the Cochrane Library, the Science Citation Index, the China National Knowledge Infrastructure Database, and the Wanfang Database. A meta‐analysis of all RCTs comparing ecabet sodium supplementation with nonecabet sodium‐containing therapy was performed. Results Thirteen RCTs that included a total of 1808 patients were assessed. The meta‐analysis showed that the eradication rate in the ecabet sodium‐containing quadruple therapy group was higher than that in the standard triple therapy group (84.5% vs 74.55%, OR 1.757 (95%CI: 1.307 to 2.362), p