A Trimeric HIV-1 gp140-BAFF Fusion Construct Enhances Mucosal Anti-trimeric HIV-1 gp140 IgA in Mice

Background: Although trimeric HIV-1 gp140 can mimic native HIV-1 envelope (Env) spikes on viral surface, derived vaccines still can not induce potent broadly neutralizing antibodies (bNAbs). HIV-1-Env specific IgA at mucosa may block HIV-1 transmission through mucosal surface. The tumor necrosis factor superfamily members, APRIL, BAFF, and CD40L, were previously shown to promote antibody responses, including mucosal IgA. We tested whether APRIL, BAFF or CD40L conjugated HIV-1 gp140 constructs could enhance anti-HIV-1-Env mucosal IgA responses.