Local Cellular Immune Responses Precede Systemic Responses Following Intravaginal SIV Infection in Rhesus Monkeys

Local Cellular Immune Responses Precede Systemic Responses Following Intravaginal SIV Infection in Rhesus Monkeys

Background: Defining the earliest immunologic events following virus exposure will be critical for the design of an effective HIV-1 vaccine. In this study, we investigated the anatomic localization of mucosal and systemic SIV-specific cellular immune responses in rhesus monkeys following intravagina...

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Veröffentlicht in:AIDS research and human retroviruses 2013-11, Vol.29 (11), p.A-118
Hauptverfasser: Liu, J, Li, H, Smith, K, Borducchi, E, Stanley, K, Wagner, W, Lewis, M, Barouch, D
Format: Artikel
Sprache:eng
Schlagworte:
Human immunodeficiency virus 1
Macaca mulatta
Retrovirus
Simian immunodeficiency virus
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Zusammenfassung:Background: Defining the earliest immunologic events following virus exposure will be critical for the design of an effective HIV-1 vaccine. In this study, we investigated the anatomic localization of mucosal and systemic SIV-specific cellular immune responses in rhesus monkeys following intravaginal infection with SIVmac251.
ISSN:0889-2229