Optimized Multidrug-Resistant HIV-1 Reverse Transcriptase Induces Strong Immune Responses in DNA-Immunized Mice

Optimized Multidrug-Resistant HIV-1 Reverse Transcriptase Induces Strong Immune Responses in DNA-Immunized Mice

Background: Development ofmultigene DNA-vaccines against HIV faces a problem of low immunogenic performance of enzymes genes, in particularly reverse transcriptase (RT). Under the pressure of antiretroviral drugs, RT accumulates mutations. Mutated protein escapes the effect of drugs, but at the same...

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Veröffentlicht in:AIDS research and human retroviruses 2013-11, Vol.29 (11), p.A-162
Hauptverfasser: Isaguliants, M, Starodubova, E, Petkov, S, Kilpelainen, A, Glowacki, G, Krotova, O, Karpov, V, Wahren, B
Format: Artikel
Sprache:eng
Schlagworte:
Human immunodeficiency virus 1
Retrovirus
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Zusammenfassung:Background: Development ofmultigene DNA-vaccines against HIV faces a problem of low immunogenic performance of enzymes genes, in particularly reverse transcriptase (RT). Under the pressure of antiretroviral drugs, RT accumulates mutations. Mutated protein escapes the effect of drugs, but at the same time becomes more immunogenic. Basing on this, we designed a new DNA-immunogen encoding RT with multiple drug-resistance mutations, and tested its performance in preclinical trials.
ISSN:0889-2229