Optimization of Automated Liquid Handlers: Regular Instrument Performance Checks Help Ensure Accurate Reagent Volume Transfer

Over the past 20 years, laboratories around the world have been turning to liquid handling robots to increase the throughput and reproducibility of a wide range of assays. This widespread implementation of automation has contributed to significant advances in our understanding of science and medicine. Speed and reproducibility, however, do not guarantee accurate assay results. Assay results are dependent on reagent concentrations, which are volume-dependent. If a liquid handler is inaccurate in the volumesit dispenses, actual reagent concentrations can vary dramatically from those intended.