Restoration of miR-193b sensitizes Hepatitis B virus-associated hepatocellular carcinoma to sorafenib

Highlights • HBV infection in HCC cell lines enhances sorafenib resistance. • HBV infection in HCC reduces miR-193b expression and increases Mcl-1 expression. • MiR-193b directly suppresses the expression of Mcl-1 through its 3′-UTRs. • MiR-193b facilitates sorafenib-induced apoptosis. • MiR-193b se...

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Veröffentlicht in:	Cancer letters 2014-10, Vol.352 (2), p.245-252
Hauptverfasser:	Mao, Kai, Zhang, Jianlong, He, Chuanchao, Xu, Kang, Liu, Jieqiong, Sun, Jian, Wu, Gang, Tan, Cui, Zeng, Yunjie, Wang, Jie, Xiao, Zhiyu
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions Angiogenesis Apoptosis Apoptosis - drug effects Cancer therapies Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Carcinoma, Hepatocellular - virology Caspase 3 - metabolism Cell growth Cell Survival - drug effects Deoxyribonucleic acid DNA DNA methylation Dose-Response Relationship, Drug Drug Resistance, Neoplasm Epigenetics Genes, Reporter Hematology, Oncology and Palliative Medicine Hep G2 Cells Hepatitis Hepatitis B virus Hepatitis B virus - genetics Hepatitis B virus - pathogenicity Hepatocellular carcinoma Humans Infections Kinases Leukemia Liver cancer Liver Neoplasms - genetics Liver Neoplasms - metabolism Liver Neoplasms - pathology Liver Neoplasms - virology Medical prognosis MicroRNAs - genetics MicroRNAs - metabolism MiR-193b Myeloid Cell Leukemia Sequence 1 Protein - genetics Myeloid Cell Leukemia Sequence 1 Protein - metabolism Myeloid cell leukemia-1 Niacinamide - analogs & derivatives Niacinamide - pharmacology Pathogenesis Phenylurea Compounds - pharmacology Protein Kinase Inhibitors - pharmacology Proteins Sorafenib Time Factors Transfection
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Beschreibung
Zusammenfassung:	Highlights • HBV infection in HCC cell lines enhances sorafenib resistance. • HBV infection in HCC reduces miR-193b expression and increases Mcl-1 expression. • MiR-193b directly suppresses the expression of Mcl-1 through its 3′-UTRs. • MiR-193b facilitates sorafenib-induced apoptosis. • MiR-193b sensitizes HBV-associated HCC cell lines to sorafenib.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2014.07.004