Interplay Between Broadly Cross-Neutralizing V2 Monoclonal Antibodies and Autologous Viral Evolution

Interplay Between Broadly Cross-Neutralizing V2 Monoclonal Antibodies and Autologous Viral Evolution

Background: CAP256, an HIV-1 subtype C superinfected individual, developed potent broadly cross-neutralizing (BCN) V2 plasmaantibodies thatwere critically dependent on R166 andK169. Eleven related BCNmAbs targeting V2 have recently been isolated from this individual after 30 months post-infection (p...

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Veröffentlicht in:AIDS research and human retroviruses 2013-11, Vol.29 (11), p.A-12
Hauptverfasser: Bhiman, J N, Doria-Rose, N, Moore, P L, Nonyane, M, Karim, S S Abdool, Kwong, P D, Mascola, J R, Morris, L
Format: Artikel
Sprache:eng
Schlagworte:
Human immunodeficiency virus 1
Retrovirus
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Zusammenfassung:Background: CAP256, an HIV-1 subtype C superinfected individual, developed potent broadly cross-neutralizing (BCN) V2 plasmaantibodies thatwere critically dependent on R166 andK169. Eleven related BCNmAbs targeting V2 have recently been isolated from this individual after 30 months post-infection (p.i.). Here we investigated the relationship between these mAbs, longitudinal CAP256 viruses and previously characterized escape variants.
ISSN:0889-2229