Delivery of Encapsulated Nod Ligands Enhance Their Ability to Induce Mucosal Immune Responses Against HIV-1 Gag After Systemic or Mucosal Immunization

Delivery of Encapsulated Nod Ligands Enhance Their Ability to Induce Mucosal Immune Responses Against HIV-1 Gag After Systemic or Mucosal Immunization

Background: TLR ligands as mucosal adjuvants for vaccine administration are already largely described whereas the use of Nod-like receptor ligands is still investigated. As activation of Nod receptors is able to induce pro-inflammatory cytokines, we have evaluated if co-delivery of those ligands int...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:AIDS research and human retroviruses 2013-11, Vol.29 (11), p.107-107
Hauptverfasser: Pavot, V, Rochereau, N, Genin, C, Perouzel, E, Lioux, T, Garcia, F, Paul, S, Verrier, B
Format: Artikel
Sprache:eng
Schlagworte:
Human immunodeficiency virus 1
Retrovirus
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Background: TLR ligands as mucosal adjuvants for vaccine administration are already largely described whereas the use of Nod-like receptor ligands is still investigated. As activation of Nod receptors is able to induce pro-inflammatory cytokines, we have evaluated if co-delivery of those ligands into biodegradable nanocarriers carrying HIV-Gag antigen could amplify the mucosal immune responses in mice after mucosal or subcutaneous administration.
ISSN:0889-2229