Immunogenicity of HIV Virus-Like Particles in Rhesus Macaques by Intra-Nasal Administration

Immunogenicity of HIV Virus-Like Particles in Rhesus Macaques by Intra-Nasal Administration

Background: The development of vaccination strategies able to elicit protective systemic and mucosal immune response represent a major goal in the HIV vaccine field. To this aim we have evaluated the immunogenicity of HIV-VLPs in Rhesus Macaques by a sequential combination of mucosal (intra-nasal, i...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:AIDS research and human retroviruses 2013-11, Vol.29 (11), p.A-31
Hauptverfasser: Buonaguro, L, Tagliamonte, M, Visciano, M, Andersen, H, Lewis, M, Pal, R, Tornesello, M, Schroeder, U, Hinkula, J, Wahren, B, Buonaguro, F M
Format: Artikel
Sprache:eng
Schlagworte:
Human immunodeficiency virus
Macaca mulatta
Retrovirus
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Background: The development of vaccination strategies able to elicit protective systemic and mucosal immune response represent a major goal in the HIV vaccine field. To this aim we have evaluated the immunogenicity of HIV-VLPs in Rhesus Macaques by a sequential combination of mucosal (intra-nasal, i.n.) and systemic (intra-muscular, i.m.) routes, according to homologous (VLP+VLP) or heterologous (DNA+VLP) prime-boost schedules.
ISSN:0889-2229