High Proportion of Simian Immunodeficiency Virus gp120- Reactive Antibodies in B Cell Repertoire of Chronically Infected African Green Monkeys

High Proportion of Simian Immunodeficiency Virus gp120- Reactive Antibodies in B Cell Repertoire of Chronically Infected African Green Monkeys

Background: Natural hosts of Simian Immunodeficiency Virus (SIV), such as African green monkeys (AGMs), rarely transmit the virus to their infant. Moreover, SIV-infected AGMs have strong autologous virus neutralizing antibody responses in milk, unlike humans and rhesus monkeys. Therefore, defining t...

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Veröffentlicht in:AIDS research and human retroviruses 2013-11, Vol.29 (11), p.A-165
Hauptverfasser: Arifin, T, Zhang, R, Stolarchuk, C, Fougler, A, Amos, J, Wang, M, Vandergrift, N, Smith, S, Colvin, L, Dewar, K, Juretic, N, Wasserscheid, J, Liao, H, Permar, S
Format: Artikel
Sprache:eng
Schlagworte:
Macaca mulatta
Retrovirus
Simian immunodeficiency virus
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Zusammenfassung:Background: Natural hosts of Simian Immunodeficiency Virus (SIV), such as African green monkeys (AGMs), rarely transmit the virus to their infant. Moreover, SIV-infected AGMs have strong autologous virus neutralizing antibody responses in milk, unlike humans and rhesus monkeys. Therefore, defining the SIV Envelope (Env)-specific B cell repertoire of AGMs could guide development of vaccines that elicit protective mucosal antibody responses.
ISSN:0889-2229