Development of Novel Simian Adenovirus Based Vaccine Vectors

Development of Novel Simian Adenovirus Based Vaccine Vectors

Background: Human adenovirus serotype 5 is a potent vaccine vector, but its use has been hampered by high seroprevalence amongst people in sub-Sahara Africa. Novel adenoviral vaccine vectors from strains with lower seroprevalence worldwide are being developed that can evade pre-existing immunity. He...

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Veröffentlicht in:AIDS research and human retroviruses 2013-11, Vol.29 (11), p.A-138
Hauptverfasser: Abbink, P, Maxfield, L, Nganga, D, Cama, Z, Ball, F, Bleckwehl, C, Borducchi, E, Barouch, D H
Format: Artikel
Sprache:eng
Schlagworte:
Adenovirus
Human adenovirus
Retrovirus
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Zusammenfassung:Background: Human adenovirus serotype 5 is a potent vaccine vector, but its use has been hampered by high seroprevalence amongst people in sub-Sahara Africa. Novel adenoviral vaccine vectors from strains with lower seroprevalence worldwide are being developed that can evade pre-existing immunity. Here we describe the development of a panel of novel old world monkey adenovirus vaccine vectors.
ISSN:0889-2229