Comprehensive DNA methylation and extensive mutation analyses reveal an association between the CpG island methylator phenotype and oncogenic mutations in gastric cancers
Highlights ► Comprehensive analysis of methylated genes revealed high variability in their numbers in gastric cancers (GCs). ► Analysis of 55 known cancer-related genes by personal sequencer revealed that 63% of GCs had one somatic mutation or more. ► The association between the CIMP and oncogene mu...
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| Veröffentlicht in: | Cancer letters 2013-03, Vol.330 (1), p.33-40 |
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| container_title | Cancer letters |
| container_volume | 330 |
| creator | Kim, Jeong Goo Takeshima, Hideyuki Niwa, Tohru Rehnberg, Emil Shigematsu, Yasuyuki Yoda, Yukie Yamashita, Satoshi Kushima, Ryoji Maekita, Takao Ichinose, Masao Katai, Hitoshi Park, Won Sang Hong, Young Seon Park, Cho Hyun Ushijima, Toshikazu |
| description | Highlights ► Comprehensive analysis of methylated genes revealed high variability in their numbers in gastric cancers (GCs). ► Analysis of 55 known cancer-related genes by personal sequencer revealed that 63% of GCs had one somatic mutation or more. ► The association between the CIMP and oncogene mutations was revealed for the first time in GCs. |
| doi_str_mv | 10.1016/j.canlet.2012.11.022 |
| format | Article |
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All rights reserved.</rights><rights>Copyright Elsevier Limited Mar 1, 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c524t-ba2879e72b364b54f4fe0ca61cd4b475959c74cf9712c1556b793e014e24ca7d3</citedby><cites>FETCH-LOGICAL-c524t-ba2879e72b364b54f4fe0ca61cd4b475959c74cf9712c1556b793e014e24ca7d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.canlet.2012.11.022$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>315,781,785,3551,27928,27929,45999</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23196062$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Jeong Goo</creatorcontrib><creatorcontrib>Takeshima, Hideyuki</creatorcontrib><creatorcontrib>Niwa, Tohru</creatorcontrib><creatorcontrib>Rehnberg, Emil</creatorcontrib><creatorcontrib>Shigematsu, Yasuyuki</creatorcontrib><creatorcontrib>Yoda, Yukie</creatorcontrib><creatorcontrib>Yamashita, Satoshi</creatorcontrib><creatorcontrib>Kushima, Ryoji</creatorcontrib><creatorcontrib>Maekita, Takao</creatorcontrib><creatorcontrib>Ichinose, Masao</creatorcontrib><creatorcontrib>Katai, Hitoshi</creatorcontrib><creatorcontrib>Park, Won Sang</creatorcontrib><creatorcontrib>Hong, Young Seon</creatorcontrib><creatorcontrib>Park, Cho Hyun</creatorcontrib><creatorcontrib>Ushijima, Toshikazu</creatorcontrib><title>Comprehensive DNA methylation and extensive mutation analyses reveal an association between the CpG island methylator phenotype and oncogenic mutations in gastric cancers</title><title>Cancer letters</title><addtitle>Cancer Lett</addtitle><description>Highlights ► Comprehensive analysis of methylated genes revealed high variability in their numbers in gastric cancers (GCs). ► Analysis of 55 known cancer-related genes by personal sequencer revealed that 63% of GCs had one somatic mutation or more. ► The association between the CIMP and oncogene mutations was revealed for the first time in GCs.</description><subject>Aberrant DNA methylation</subject><subject>Cancer</subject><subject>CIMP</subject><subject>CpG Islands</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA Methylation</subject><subject>DNA Mutational Analysis - methods</subject><subject>DNA, Neoplasm - genetics</subject><subject>DNA, Neoplasm - metabolism</subject><subject>Epigenesis, Genetic</subject><subject>Epigenetics</subject><subject>Female</subject><subject>Gastric cancer</subject><subject>Gene Expression</subject><subject>Genes</subject><subject>Genotype & phenotype</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Humans</subject><subject>Infections</subject><subject>Male</subject><subject>Mutation</subject><subject>Mutation, Missense</subject><subject>Phenotype</subject><subject>Stomach Neoplasms - genetics</subject><subject>Stomach Neoplasms - metabolism</subject><issn>0304-3835</issn><issn>1872-7980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUk1v1DAQjRCILoV_gJAlLlwS_BUnuSBVW1qQKjgAZ8txJl0vSRxsZyF_qb8Sh-wWqZeeLM-8eU9v3iTJa4Izgol4v8-0GjoIGcWEZoRkmNInyYaUBU2LqsRPkw1mmKesZPlZ8sL7PcY450X-PDmjjFQCC7pJ7ra2Hx3sYPDmAOjyywXqIezmTgVjB6SGBsGfcOz2UziVVTd78MjBAVQX_0h5b7VZ2zWE3wADCjtA2_EaGd8tRCdi69AYBW2YR_inYAdtb2Ew-l7BIzOgW-WDi8XoU4PzL5Nnreo8vDq-58mPq4_ft5_Sm6_Xn7cXN6nOKQ9prWhZVFDQmgle57zlLWCtBNENr6P9Kq90wXVbFYRqkueiLioGmHCgXKuiYefJu5V3dPbXBD7I3ngNXfQAdvKS5EKUtOKMPQ6lJS0jjvMIffsAureTi3tcCHNSMEYIjii-orSz3jto5ehMr9wsCZZL7HIv19jlErskRMbY49ibI_lU99DcD51yjoAPKwDi4g4GnPTaQFxrYxzoIBtrHlN4SKA7ExNT3U-Ywf_3Ij2VWH5bTm-5PEIxFqIS7C9mNte6</recordid><startdate>20130301</startdate><enddate>20130301</enddate><creator>Kim, Jeong Goo</creator><creator>Takeshima, Hideyuki</creator><creator>Niwa, Tohru</creator><creator>Rehnberg, Emil</creator><creator>Shigematsu, Yasuyuki</creator><creator>Yoda, Yukie</creator><creator>Yamashita, Satoshi</creator><creator>Kushima, Ryoji</creator><creator>Maekita, Takao</creator><creator>Ichinose, Masao</creator><creator>Katai, Hitoshi</creator><creator>Park, Won Sang</creator><creator>Hong, Young Seon</creator><creator>Park, Cho Hyun</creator><creator>Ushijima, Toshikazu</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>7TM</scope></search><sort><creationdate>20130301</creationdate><title>Comprehensive DNA methylation and extensive mutation analyses reveal an association between the CpG island methylator phenotype and oncogenic mutations in gastric cancers</title><author>Kim, Jeong Goo ; Takeshima, Hideyuki ; Niwa, Tohru ; Rehnberg, Emil ; Shigematsu, Yasuyuki ; Yoda, Yukie ; Yamashita, Satoshi ; Kushima, Ryoji ; Maekita, Takao ; Ichinose, Masao ; Katai, Hitoshi ; Park, Won Sang ; Hong, Young Seon ; Park, Cho Hyun ; Ushijima, Toshikazu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c524t-ba2879e72b364b54f4fe0ca61cd4b475959c74cf9712c1556b793e014e24ca7d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Aberrant DNA methylation</topic><topic>Cancer</topic><topic>CIMP</topic><topic>CpG Islands</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA Methylation</topic><topic>DNA Mutational Analysis - 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| identifier | ISSN: 0304-3835 |
| ispartof | Cancer letters, 2013-03, Vol.330 (1), p.33-40 |
| issn | 0304-3835 1872-7980 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Aberrant DNA methylation Cancer CIMP CpG Islands Deoxyribonucleic acid DNA DNA Methylation DNA Mutational Analysis - methods DNA, Neoplasm - genetics DNA, Neoplasm - metabolism Epigenesis, Genetic Epigenetics Female Gastric cancer Gene Expression Genes Genotype & phenotype Hematology, Oncology and Palliative Medicine Humans Infections Male Mutation Mutation, Missense Phenotype Stomach Neoplasms - genetics Stomach Neoplasms - metabolism |
| title | Comprehensive DNA methylation and extensive mutation analyses reveal an association between the CpG island methylator phenotype and oncogenic mutations in gastric cancers |
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