Comprehensive DNA methylation and extensive mutation analyses reveal an association between the CpG island methylator phenotype and oncogenic mutations in gastric cancers

Highlights ► Comprehensive analysis of methylated genes revealed high variability in their numbers in gastric cancers (GCs). ► Analysis of 55 known cancer-related genes by personal sequencer revealed that 63% of GCs had one somatic mutation or more. ► The association between the CIMP and oncogene mu...

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Veröffentlicht in:	Cancer letters 2013-03, Vol.330 (1), p.33-40
Hauptverfasser:	Kim, Jeong Goo, Takeshima, Hideyuki, Niwa, Tohru, Rehnberg, Emil, Shigematsu, Yasuyuki, Yoda, Yukie, Yamashita, Satoshi, Kushima, Ryoji, Maekita, Takao, Ichinose, Masao, Katai, Hitoshi, Park, Won Sang, Hong, Young Seon, Park, Cho Hyun, Ushijima, Toshikazu
Format:	Artikel
Sprache:	eng
Schlagworte:	Aberrant DNA methylation Cancer CIMP CpG Islands Deoxyribonucleic acid DNA DNA Methylation DNA Mutational Analysis - methods DNA, Neoplasm - genetics DNA, Neoplasm - metabolism Epigenesis, Genetic Epigenetics Female Gastric cancer Gene Expression Genes Genotype & phenotype Hematology, Oncology and Palliative Medicine Humans Infections Male Mutation Mutation, Missense Phenotype Stomach Neoplasms - genetics Stomach Neoplasms - metabolism
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Zusammenfassung:	Highlights ► Comprehensive analysis of methylated genes revealed high variability in their numbers in gastric cancers (GCs). ► Analysis of 55 known cancer-related genes by personal sequencer revealed that 63% of GCs had one somatic mutation or more. ► The association between the CIMP and oncogene mutations was revealed for the first time in GCs.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2012.11.022