Transforming growth factor-β1-induced epithelial–mesenchymal transition generates ALDH-positive cells with stem cell properties in cholangiocarcinoma

Highlights • TGF-β1-induced EMT promotes cancer stem cell-like properties. • ALDH acts as a marker for cancer stem cells in cholangiocarcinoma. • The expressions of TGF-β1 and ALDH1 can predict the prognosis of cholangiocarcinoma.

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Bibliographische Detailangaben
Veröffentlicht in:	Cancer letters 2014-11, Vol.354 (2), p.320-328
Hauptverfasser:	Shuang, Ze-Yu, Wu, Wen-Chao, Xu, Jing, Lin, Guohe, Liu, Yong-Cheng, Lao, Xiang-Ming, Zheng, Limin, Li, Shengping
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehyde dehydrogenase Aldehyde Dehydrogenase - metabolism Animals Bile Duct Neoplasms - enzymology Bile Duct Neoplasms - pathology Bile Ducts, Intrahepatic - drug effects Bile Ducts, Intrahepatic - enzymology Bile Ducts, Intrahepatic - pathology Cancer stem cells Cell Line, Tumor Cholangiocarcinoma Cholangiocarcinoma - enzymology Cholangiocarcinoma - pathology Epithelial-Mesenchymal Transition - drug effects Epithelial–mesenchymal transition Hematology, Oncology and Palliative Medicine Humans Male Mice Mice, Inbred NOD Mice, SCID Neoplastic Stem Cells - drug effects Neoplastic Stem Cells - enzymology Neoplastic Stem Cells - pathology Transforming Growth Factor beta1 - pharmacology Transforming growth factor-β1
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Beschreibung
Zusammenfassung:	Highlights • TGF-β1-induced EMT promotes cancer stem cell-like properties. • ALDH acts as a marker for cancer stem cells in cholangiocarcinoma. • The expressions of TGF-β1 and ALDH1 can predict the prognosis of cholangiocarcinoma.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2014.08.030