Add-on clinical effects of selective antagonist of 5HT6 receptors AVN-211 (CD-008-0173) in patients with schizophrenia stabilized on antipsychotic treatment: pilot study

The serotoninergic system as a target for add-on treatment seems to be a promising approach in patients with schizophrenia.

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Bibliographische Detailangaben
Veröffentlicht in:	CNS spectrums 2014-08, Vol.19 (4), p.316-323
Hauptverfasser:	Morozova, Margarita A., Lepilkina, Taisiya A., Rupchev, Georgy E., Beniashvily, Allan G., Burminskiy, Denis S., Potanin, Sergey S., Bondarenko, Evgeny V., Kazey, Vasily I., Lavrovsky, Yan, Ivachtchenko, Alexandre V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acoustics Adult Alzheimer's disease Anesthesia Animals Antipsychotic Agents - therapeutic use Antipsychotics Attention Behavior, Animal - drug effects Cholinergic Antagonists - pharmacology Cholinesterase Inhibitors - pharmacology Cognition Double-Blind Method Double-blind studies Drug dosages Drug Therapy, Combination Female Humans Indans - pharmacology Male Maze Learning - drug effects Mice Mice, Inbred BALB C Middle Aged Original Research Physiology Pilot Projects Piperidines - pharmacology Prepulse Inhibition - drug effects Psychopathology Psychosis Psychotropic drugs Pyrazoles - pharmacology Pyrazoles - therapeutic use Pyrimidines - pharmacology Pyrimidines - therapeutic use Reaction Time Receptors, Serotonin Reflex, Startle - drug effects Remission (Medicine) Schizophrenia Schizophrenia - drug therapy Schizophrenic Psychology Scopolamine Hydrobromide - pharmacology Serotonin Antagonists - pharmacology Serotonin Antagonists - therapeutic use Tacrine - pharmacology Treatment Outcome Young Adult
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Beschreibung
Zusammenfassung:	The serotoninergic system as a target for add-on treatment seems to be a promising approach in patients with schizophrenia.
ISSN:	1092-8529 2165-6509
DOI:	10.1017/S1092852913000394