The immunological effects of oral polio vaccine provided with BCG vaccine at birth: A randomised trial

Highlights • Newborns were randomised to OPV at birth (OPV0) together with BCG vs BCG alone. • In vitro cytokine responses to PPD and BCG were reduced in the OPV + BCG group. • Innate responses, cell distribution or inflammation markers were not affected. • The first randomised trial showing heterol...

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Veröffentlicht in:	Vaccine 2014-10, Vol.32 (45), p.5949-5956
Hauptverfasser:	Jensen, Kristoffer Jarlov, Karkov, Hanne Sophie, Lund, Najaaraq, Andersen, Andreas, Eriksen, Helle Brander, Barbosa, Amarildo Gomes, Kantsø, Bjørn, Aaby, Peter, Benn, Christine Stabell
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Applied microbiology Babies Bacillus Calmette-Guérin Bacteriology BCG Vaccine - administration & dosage BCG Vaccine - immunology Biological and medical sciences Cytokines Cytokines - immunology Female Fundamental and applied biological sciences. Psychology Guinea-Bissau Heterologous immunity Human viral diseases Humans Immune response Immunology Infant Infant, Newborn Infants Infectious diseases Interferon-gamma - immunology Male Medical sciences Microbiology Miscellaneous NCT00710983 Non-specific effect Observational studies Oral polio vaccine Poliovirus Vaccine, Oral - administration & dosage Poliovirus Vaccine, Oral - immunology Proteins Studies Tuberculosis Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Viral diseases Viral diseases of the nervous system
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Beschreibung
Zusammenfassung:	Highlights • Newborns were randomised to OPV at birth (OPV0) together with BCG vs BCG alone. • In vitro cytokine responses to PPD and BCG were reduced in the OPV + BCG group. • Innate responses, cell distribution or inflammation markers were not affected. • The first randomised trial showing heterologous immunological effects of OPV0.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2014.08.062