Differential expression of mitochondrial energy metabolism profiles across the metaplasia–dysplasia–adenocarcinoma disease sequence in Barrett's oesophagus
Highlights • Various cancer types demonstrate alterations in mitochondrial energy metabolism. • Mitochondrial energy metabolism is altered across the Barrett's disease sequence. • Shifts in oxidative phosphorylation and glycolysis characterise these alterations. • Barrett's oesophagus lack...
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| Veröffentlicht in: | Cancer letters 2014-11, Vol.354 (1), p.122-131 |
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| container_title | Cancer letters |
| container_volume | 354 |
| creator | Phelan, J.J MacCarthy, F Feighery, R O'Farrell, N.J Lynam-Lennon, N Doyle, B O'Toole, D Ravi, N Reynolds, J.V O'Sullivan, J |
| description | Highlights • Various cancer types demonstrate alterations in mitochondrial energy metabolism. • Mitochondrial energy metabolism is altered across the Barrett's disease sequence. • Shifts in oxidative phosphorylation and glycolysis characterise these alterations. • Barrett's oesophagus lacks accurate predictors of disease progression to cancer. • ATP5B segregates Barrett's non progressors and progressors to oesophageal cancer. |
| doi_str_mv | 10.1016/j.canlet.2014.07.035 |
| format | Article |
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All rights reserved.</rights><rights>Copyright Elsevier Limited Nov 1, 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c561t-12e83f51a36efc1c9f0b7404a1745b0f9e1dfdc7a88d5d610c591ba8958209ca3</citedby><cites>FETCH-LOGICAL-c561t-12e83f51a36efc1c9f0b7404a1745b0f9e1dfdc7a88d5d610c591ba8958209ca3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0304383514004145$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25107643$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Phelan, J.J</creatorcontrib><creatorcontrib>MacCarthy, F</creatorcontrib><creatorcontrib>Feighery, R</creatorcontrib><creatorcontrib>O'Farrell, N.J</creatorcontrib><creatorcontrib>Lynam-Lennon, N</creatorcontrib><creatorcontrib>Doyle, B</creatorcontrib><creatorcontrib>O'Toole, D</creatorcontrib><creatorcontrib>Ravi, N</creatorcontrib><creatorcontrib>Reynolds, J.V</creatorcontrib><creatorcontrib>O'Sullivan, J</creatorcontrib><title>Differential expression of mitochondrial energy metabolism profiles across the metaplasia–dysplasia–adenocarcinoma disease sequence in Barrett's oesophagus</title><title>Cancer letters</title><addtitle>Cancer Lett</addtitle><description>Highlights • Various cancer types demonstrate alterations in mitochondrial energy metabolism. • Mitochondrial energy metabolism is altered across the Barrett's disease sequence. • Shifts in oxidative phosphorylation and glycolysis characterise these alterations. • Barrett's oesophagus lacks accurate predictors of disease progression to cancer. • ATP5B segregates Barrett's non progressors and progressors to oesophageal cancer.</description><subject>Adenocarcinoma - metabolism</subject><subject>Barrett Esophagus - metabolism</subject><subject>Barrett Esophagus - pathology</subject><subject>Barrett's metaplasia</subject><subject>Biopsy</subject><subject>Cancer</subject><subject>Cell Line, Tumor</subject><subject>Disease Progression</subject><subject>DNA repair</subject><subject>Electron Transport Complex IV - metabolism</subject><subject>Energy Metabolism</subject><subject>Enzymes</subject><subject>Free radicals</subject><subject>Gene expression</subject><subject>Gene Expression Profiling</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Glycolysis</subject><subject>H(+)-K(+)-Exchanging ATPase - metabolism</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Humans</subject><subject>Medical prognosis</subject><subject>Metabolism</subject><subject>Metaplasia - metabolism</subject><subject>Mitochondria</subject><subject>Mitochondria - metabolism</subject><subject>Mitochondrial dysfunction</subject><subject>Mitochondrial energy metabolism</subject><subject>Oesophageal cancer</subject><subject>Oligonucleotide Array Sequence Analysis</subject><subject>Oxidative phosphorylation</subject><subject>Oxygen - chemistry</subject><subject>Phosphorylation</subject><subject>Proteins</subject><subject>Studies</subject><issn>0304-3835</issn><issn>1872-7980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkktuFDEQhlsIRIbADRCyxIJsZii37X5skCDhJUViAawtt13OeOi2G1cPYnbcgQNwN05Cz0wIUjasXFJ9Va76_yqKxxxWHHj1fLOyJvY4rUrgcgX1CoS6Uyx4U5fLum3gbrEAAXIpGqFOigdEGwBQslb3i5NScagrKRbFr4vgPWaMUzA9w-9jRqKQIkueDWFKdp2iy4dcxHy1YwNOpkt9oIGNOfnQIzFjcyJi0xoP6bE3FMzvHz_djm5i4zAma7INMQ2GuUBoCBnh1y1GiyxE9srkjNP0jFhCSuPaXG3pYXHPm57w0fV7Wnx-8_rT-bvl5Ye3789fXi6tqvi05CU2wituRIXectt66GoJ0vBaqg58i9x5Z2vTNE65ioNVLe9M06qmhNYacVqcHfvOS80T0aSHQBb73kRMW9JcVZXkAKKd0ae30E3a5jhPp3k1m1EpUcqZkkfqoE1Gr8ccBpN3moPeG6g3-mig3huoodazgXPZk-vm225Ad1P017EZeHEEcFbjW8CsyYa9gi5ktJN2Kfzvh9sNbB9isKb_gjukf7toKjXoj_sj2t8QlwCSSyX-ACpMySg</recordid><startdate>20141101</startdate><enddate>20141101</enddate><creator>Phelan, J.J</creator><creator>MacCarthy, F</creator><creator>Feighery, R</creator><creator>O'Farrell, N.J</creator><creator>Lynam-Lennon, N</creator><creator>Doyle, B</creator><creator>O'Toole, D</creator><creator>Ravi, N</creator><creator>Reynolds, J.V</creator><creator>O'Sullivan, J</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20141101</creationdate><title>Differential expression of mitochondrial energy metabolism profiles across the metaplasia–dysplasia–adenocarcinoma disease sequence in Barrett's oesophagus</title><author>Phelan, J.J ; MacCarthy, F ; Feighery, R ; O'Farrell, N.J ; Lynam-Lennon, N ; Doyle, B ; O'Toole, D ; Ravi, N ; Reynolds, J.V ; O'Sullivan, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c561t-12e83f51a36efc1c9f0b7404a1745b0f9e1dfdc7a88d5d610c591ba8958209ca3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adenocarcinoma - 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| ispartof | Cancer letters, 2014-11, Vol.354 (1), p.122-131 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adenocarcinoma - metabolism Barrett Esophagus - metabolism Barrett Esophagus - pathology Barrett's metaplasia Biopsy Cancer Cell Line, Tumor Disease Progression DNA repair Electron Transport Complex IV - metabolism Energy Metabolism Enzymes Free radicals Gene expression Gene Expression Profiling Gene Expression Regulation, Neoplastic Glycolysis H(+)-K(+)-Exchanging ATPase - metabolism Hematology, Oncology and Palliative Medicine Humans Medical prognosis Metabolism Metaplasia - metabolism Mitochondria Mitochondria - metabolism Mitochondrial dysfunction Mitochondrial energy metabolism Oesophageal cancer Oligonucleotide Array Sequence Analysis Oxidative phosphorylation Oxygen - chemistry Phosphorylation Proteins Studies |
| title | Differential expression of mitochondrial energy metabolism profiles across the metaplasia–dysplasia–adenocarcinoma disease sequence in Barrett's oesophagus |
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