Differential expression of mitochondrial energy metabolism profiles across the metaplasia–dysplasia–adenocarcinoma disease sequence in Barrett's oesophagus

Highlights • Various cancer types demonstrate alterations in mitochondrial energy metabolism. • Mitochondrial energy metabolism is altered across the Barrett's disease sequence. • Shifts in oxidative phosphorylation and glycolysis characterise these alterations. • Barrett's oesophagus lack...

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Veröffentlicht in:	Cancer letters 2014-11, Vol.354 (1), p.122-131
Hauptverfasser:	Phelan, J.J, MacCarthy, F, Feighery, R, O'Farrell, N.J, Lynam-Lennon, N, Doyle, B, O'Toole, D, Ravi, N, Reynolds, J.V, O'Sullivan, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - metabolism Barrett Esophagus - metabolism Barrett Esophagus - pathology Barrett's metaplasia Biopsy Cancer Cell Line, Tumor Disease Progression DNA repair Electron Transport Complex IV - metabolism Energy Metabolism Enzymes Free radicals Gene expression Gene Expression Profiling Gene Expression Regulation, Neoplastic Glycolysis H(+)-K(+)-Exchanging ATPase - metabolism Hematology, Oncology and Palliative Medicine Humans Medical prognosis Metabolism Metaplasia - metabolism Mitochondria Mitochondria - metabolism Mitochondrial dysfunction Mitochondrial energy metabolism Oesophageal cancer Oligonucleotide Array Sequence Analysis Oxidative phosphorylation Oxygen - chemistry Phosphorylation Proteins Studies
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Zusammenfassung:	Highlights • Various cancer types demonstrate alterations in mitochondrial energy metabolism. • Mitochondrial energy metabolism is altered across the Barrett's disease sequence. • Shifts in oxidative phosphorylation and glycolysis characterise these alterations. • Barrett's oesophagus lacks accurate predictors of disease progression to cancer. • ATP5B segregates Barrett's non progressors and progressors to oesophageal cancer.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2014.07.035