Upregulation of intestinal glucose transporters after Roux‐en‐Y gastric bypass to prevent carbohydrate malabsorption
Objective To determine the effect of Roux‐en‐Y gastric bypass (RYGB) on the expression of intestinal sweet taste receptors (STRs), glucose transporters (GTs), glucose absorption, and glycemia. Methods Intestinal biopsies were collected for mRNA expression of STR (T1R2) and GTs (SGLT‐1 and GLUT2) fro...
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| Veröffentlicht in: | Obesity (Silver Spring, Md.) Md.), 2014-10, Vol.22 (10), p.2164-2171 |
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| container_title | Obesity (Silver Spring, Md.) |
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| creator | Nguyen, Nam Q. Debreceni, Tamara L. Bambrick, Jenna E. Chia, Bridgette Deane, Adam M. Wittert, Gary Rayner, Chris K. Horowitz, Michael Young, Richard L. |
| description | Objective
To determine the effect of Roux‐en‐Y gastric bypass (RYGB) on the expression of intestinal sweet taste receptors (STRs), glucose transporters (GTs), glucose absorption, and glycemia.
Methods
Intestinal biopsies were collected for mRNA expression of STR (T1R2) and GTs (SGLT‐1 and GLUT2) from 11 non‐diabetic RYGB, 13 non‐diabetic obese, and 11 healthy subjects, at baseline and following a 30 min small intestinal (SI) glucose infusion (30 g/150 ml water with 3 g 3‐O‐methyl‐d‐glucopyranose (3‐OMG)). Blood glucose, plasma 3‐OMG, and insulin were measured for 270 min.
Results
In RYGB patients, expression of both GTs was ∼2‐fold higher at baseline and after glucose infusion than those of morbidly obese or healthy subjects (P |
| doi_str_mv | 10.1002/oby.20829 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_1566409931</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3664298531</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4249-7b568b19d3da3ceada56d35d07b155891f71f507e7bfa79f9d9d2ced87e314a03</originalsourceid><addsrcrecordid>eNpdkctKxDAUhoMojo4ufAEJuHEzTtI0TbNU8QaCIArOqpw06VjpNDVJ1e58BJ_RJzHjqAs35z9wPs7tR2iPkiNKSDK1ajhKSJ7INbRFJSMTweTD-l-e0xHa9v6JkDQjnG6iUZJKSRKab6G3-86Zed9AqG2LbYXrNhgf6hYaPG_60nqDg4PWd9YF4zyGKgq-tf3b5_uHaWOY4Tn44OoSq6ED73GwODZ9MW3AJThlHwftIBi8gAaUt65bztpBGxU03uz-6Bjdn5_dnV5Orm8urk6PrydlGrecCMWzXFGpmQZWGtDAM824JkJRznNJK0ErToQRqgIhK6mlTkqjc2EYTYGwMTpc9e2cfe7jacWi9qVpGmiN7X1BeZalREpGI3rwD32yvYufiFQmOJWCMxmp_R-qVwuji87VC3BD8fvTCExXwGvdmOGvTkmxNKuIZhXfZhU3J7PvhH0Bb2OLcQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1675197539</pqid></control><display><type>article</type><title>Upregulation of intestinal glucose transporters after Roux‐en‐Y gastric bypass to prevent carbohydrate malabsorption</title><source>MEDLINE</source><source>Wiley Online Library</source><source>Wiley Free Archive</source><creator>Nguyen, Nam Q. ; Debreceni, Tamara L. ; Bambrick, Jenna E. ; Chia, Bridgette ; Deane, Adam M. ; Wittert, Gary ; Rayner, Chris K. ; Horowitz, Michael ; Young, Richard L.</creator><creatorcontrib>Nguyen, Nam Q. ; Debreceni, Tamara L. ; Bambrick, Jenna E. ; Chia, Bridgette ; Deane, Adam M. ; Wittert, Gary ; Rayner, Chris K. ; Horowitz, Michael ; Young, Richard L.</creatorcontrib><description>Objective
To determine the effect of Roux‐en‐Y gastric bypass (RYGB) on the expression of intestinal sweet taste receptors (STRs), glucose transporters (GTs), glucose absorption, and glycemia.
Methods
Intestinal biopsies were collected for mRNA expression of STR (T1R2) and GTs (SGLT‐1 and GLUT2) from 11 non‐diabetic RYGB, 13 non‐diabetic obese, and 11 healthy subjects, at baseline and following a 30 min small intestinal (SI) glucose infusion (30 g/150 ml water with 3 g 3‐O‐methyl‐d‐glucopyranose (3‐OMG)). Blood glucose, plasma 3‐OMG, and insulin were measured for 270 min.
Results
In RYGB patients, expression of both GTs was ∼2‐fold higher at baseline and after glucose infusion than those of morbidly obese or healthy subjects (P < 0.001). STR expressions were comparable amongst the groups. Peak plasma 3‐OMG in both RYGB (r = 0.69, P = 0.01) and obese (r = 0.72, P = 0.005) correlated with baseline expression of SGLT‐1, as was the case with peak blood glucose in RYGB subjects (r = 0.69, P = 0.02).
Conclusions
The upregulated intestinal GTs in RYGB patients are associated with increased glucose absorption when glucose is delivered at a physiological rate, suggesting a molecular adaptation to prevent carbohydrate malabsorption from rapid intestinal transit after RYGB.</description><identifier>ISSN: 1930-7381</identifier><identifier>EISSN: 1930-739X</identifier><identifier>DOI: 10.1002/oby.20829</identifier><identifier>PMID: 24990218</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Adult ; Age ; Biopsy ; Blood Glucose - metabolism ; Carbohydrate Metabolism ; Case-Control Studies ; Diabetes ; Female ; Gastric Bypass - adverse effects ; Gender ; Glucose ; Glucose - pharmacokinetics ; Glucose Transport Proteins, Facilitative - genetics ; Glucose Transport Proteins, Facilitative - metabolism ; Humans ; Insulin - blood ; Intestinal Absorption ; Intestines - metabolism ; Malabsorption Syndromes - genetics ; Malabsorption Syndromes - metabolism ; Malabsorption Syndromes - prevention & control ; Male ; Middle Aged ; Obesity ; Obesity, Morbid - genetics ; Obesity, Morbid - metabolism ; Obesity, Morbid - surgery ; Small intestine ; Up-Regulation - genetics</subject><ispartof>Obesity (Silver Spring, Md.), 2014-10, Vol.22 (10), p.2164-2171</ispartof><rights>Copyright © 2014 The Obesity Society</rights><rights>Copyright © 2014 The Obesity Society.</rights><rights>Copyright Blackwell Publishing Ltd. Oct 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4249-7b568b19d3da3ceada56d35d07b155891f71f507e7bfa79f9d9d2ced87e314a03</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Foby.20829$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Foby.20829$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24990218$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nguyen, Nam Q.</creatorcontrib><creatorcontrib>Debreceni, Tamara L.</creatorcontrib><creatorcontrib>Bambrick, Jenna E.</creatorcontrib><creatorcontrib>Chia, Bridgette</creatorcontrib><creatorcontrib>Deane, Adam M.</creatorcontrib><creatorcontrib>Wittert, Gary</creatorcontrib><creatorcontrib>Rayner, Chris K.</creatorcontrib><creatorcontrib>Horowitz, Michael</creatorcontrib><creatorcontrib>Young, Richard L.</creatorcontrib><title>Upregulation of intestinal glucose transporters after Roux‐en‐Y gastric bypass to prevent carbohydrate malabsorption</title><title>Obesity (Silver Spring, Md.)</title><addtitle>Obesity (Silver Spring)</addtitle><description>Objective
To determine the effect of Roux‐en‐Y gastric bypass (RYGB) on the expression of intestinal sweet taste receptors (STRs), glucose transporters (GTs), glucose absorption, and glycemia.
Methods
Intestinal biopsies were collected for mRNA expression of STR (T1R2) and GTs (SGLT‐1 and GLUT2) from 11 non‐diabetic RYGB, 13 non‐diabetic obese, and 11 healthy subjects, at baseline and following a 30 min small intestinal (SI) glucose infusion (30 g/150 ml water with 3 g 3‐O‐methyl‐d‐glucopyranose (3‐OMG)). Blood glucose, plasma 3‐OMG, and insulin were measured for 270 min.
Results
In RYGB patients, expression of both GTs was ∼2‐fold higher at baseline and after glucose infusion than those of morbidly obese or healthy subjects (P < 0.001). STR expressions were comparable amongst the groups. Peak plasma 3‐OMG in both RYGB (r = 0.69, P = 0.01) and obese (r = 0.72, P = 0.005) correlated with baseline expression of SGLT‐1, as was the case with peak blood glucose in RYGB subjects (r = 0.69, P = 0.02).
Conclusions
The upregulated intestinal GTs in RYGB patients are associated with increased glucose absorption when glucose is delivered at a physiological rate, suggesting a molecular adaptation to prevent carbohydrate malabsorption from rapid intestinal transit after RYGB.</description><subject>Adult</subject><subject>Age</subject><subject>Biopsy</subject><subject>Blood Glucose - metabolism</subject><subject>Carbohydrate Metabolism</subject><subject>Case-Control Studies</subject><subject>Diabetes</subject><subject>Female</subject><subject>Gastric Bypass - adverse effects</subject><subject>Gender</subject><subject>Glucose</subject><subject>Glucose - pharmacokinetics</subject><subject>Glucose Transport Proteins, Facilitative - genetics</subject><subject>Glucose Transport Proteins, Facilitative - metabolism</subject><subject>Humans</subject><subject>Insulin - blood</subject><subject>Intestinal Absorption</subject><subject>Intestines - metabolism</subject><subject>Malabsorption Syndromes - genetics</subject><subject>Malabsorption Syndromes - metabolism</subject><subject>Malabsorption Syndromes - prevention & control</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Obesity</subject><subject>Obesity, Morbid - genetics</subject><subject>Obesity, Morbid - metabolism</subject><subject>Obesity, Morbid - surgery</subject><subject>Small intestine</subject><subject>Up-Regulation - genetics</subject><issn>1930-7381</issn><issn>1930-739X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkctKxDAUhoMojo4ufAEJuHEzTtI0TbNU8QaCIArOqpw06VjpNDVJ1e58BJ_RJzHjqAs35z9wPs7tR2iPkiNKSDK1ajhKSJ7INbRFJSMTweTD-l-e0xHa9v6JkDQjnG6iUZJKSRKab6G3-86Zed9AqG2LbYXrNhgf6hYaPG_60nqDg4PWd9YF4zyGKgq-tf3b5_uHaWOY4Tn44OoSq6ED73GwODZ9MW3AJThlHwftIBi8gAaUt65bztpBGxU03uz-6Bjdn5_dnV5Orm8urk6PrydlGrecCMWzXFGpmQZWGtDAM824JkJRznNJK0ErToQRqgIhK6mlTkqjc2EYTYGwMTpc9e2cfe7jacWi9qVpGmiN7X1BeZalREpGI3rwD32yvYufiFQmOJWCMxmp_R-qVwuji87VC3BD8fvTCExXwGvdmOGvTkmxNKuIZhXfZhU3J7PvhH0Bb2OLcQ</recordid><startdate>201410</startdate><enddate>201410</enddate><creator>Nguyen, Nam Q.</creator><creator>Debreceni, Tamara L.</creator><creator>Bambrick, Jenna E.</creator><creator>Chia, Bridgette</creator><creator>Deane, Adam M.</creator><creator>Wittert, Gary</creator><creator>Rayner, Chris K.</creator><creator>Horowitz, Michael</creator><creator>Young, Richard L.</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201410</creationdate><title>Upregulation of intestinal glucose transporters after Roux‐en‐Y gastric bypass to prevent carbohydrate malabsorption</title><author>Nguyen, Nam Q. ; Debreceni, Tamara L. ; Bambrick, Jenna E. ; Chia, Bridgette ; Deane, Adam M. ; Wittert, Gary ; Rayner, Chris K. ; Horowitz, Michael ; Young, Richard L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4249-7b568b19d3da3ceada56d35d07b155891f71f507e7bfa79f9d9d2ced87e314a03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Age</topic><topic>Biopsy</topic><topic>Blood Glucose - metabolism</topic><topic>Carbohydrate Metabolism</topic><topic>Case-Control Studies</topic><topic>Diabetes</topic><topic>Female</topic><topic>Gastric Bypass - adverse effects</topic><topic>Gender</topic><topic>Glucose</topic><topic>Glucose - pharmacokinetics</topic><topic>Glucose Transport Proteins, Facilitative - genetics</topic><topic>Glucose Transport Proteins, Facilitative - metabolism</topic><topic>Humans</topic><topic>Insulin - blood</topic><topic>Intestinal Absorption</topic><topic>Intestines - metabolism</topic><topic>Malabsorption Syndromes - genetics</topic><topic>Malabsorption Syndromes - metabolism</topic><topic>Malabsorption Syndromes - prevention & control</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Obesity</topic><topic>Obesity, Morbid - genetics</topic><topic>Obesity, Morbid - metabolism</topic><topic>Obesity, Morbid - surgery</topic><topic>Small intestine</topic><topic>Up-Regulation - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nguyen, Nam Q.</creatorcontrib><creatorcontrib>Debreceni, Tamara L.</creatorcontrib><creatorcontrib>Bambrick, Jenna E.</creatorcontrib><creatorcontrib>Chia, Bridgette</creatorcontrib><creatorcontrib>Deane, Adam M.</creatorcontrib><creatorcontrib>Wittert, Gary</creatorcontrib><creatorcontrib>Rayner, Chris K.</creatorcontrib><creatorcontrib>Horowitz, Michael</creatorcontrib><creatorcontrib>Young, Richard L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Obesity (Silver Spring, Md.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nguyen, Nam Q.</au><au>Debreceni, Tamara L.</au><au>Bambrick, Jenna E.</au><au>Chia, Bridgette</au><au>Deane, Adam M.</au><au>Wittert, Gary</au><au>Rayner, Chris K.</au><au>Horowitz, Michael</au><au>Young, Richard L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Upregulation of intestinal glucose transporters after Roux‐en‐Y gastric bypass to prevent carbohydrate malabsorption</atitle><jtitle>Obesity (Silver Spring, Md.)</jtitle><addtitle>Obesity (Silver Spring)</addtitle><date>2014-10</date><risdate>2014</risdate><volume>22</volume><issue>10</issue><spage>2164</spage><epage>2171</epage><pages>2164-2171</pages><issn>1930-7381</issn><eissn>1930-739X</eissn><abstract>Objective
To determine the effect of Roux‐en‐Y gastric bypass (RYGB) on the expression of intestinal sweet taste receptors (STRs), glucose transporters (GTs), glucose absorption, and glycemia.
Methods
Intestinal biopsies were collected for mRNA expression of STR (T1R2) and GTs (SGLT‐1 and GLUT2) from 11 non‐diabetic RYGB, 13 non‐diabetic obese, and 11 healthy subjects, at baseline and following a 30 min small intestinal (SI) glucose infusion (30 g/150 ml water with 3 g 3‐O‐methyl‐d‐glucopyranose (3‐OMG)). Blood glucose, plasma 3‐OMG, and insulin were measured for 270 min.
Results
In RYGB patients, expression of both GTs was ∼2‐fold higher at baseline and after glucose infusion than those of morbidly obese or healthy subjects (P < 0.001). STR expressions were comparable amongst the groups. Peak plasma 3‐OMG in both RYGB (r = 0.69, P = 0.01) and obese (r = 0.72, P = 0.005) correlated with baseline expression of SGLT‐1, as was the case with peak blood glucose in RYGB subjects (r = 0.69, P = 0.02).
Conclusions
The upregulated intestinal GTs in RYGB patients are associated with increased glucose absorption when glucose is delivered at a physiological rate, suggesting a molecular adaptation to prevent carbohydrate malabsorption from rapid intestinal transit after RYGB.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>24990218</pmid><doi>10.1002/oby.20829</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1930-7381 |
| ispartof | Obesity (Silver Spring, Md.), 2014-10, Vol.22 (10), p.2164-2171 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library; Wiley Free Archive |
| subjects | Adult Age Biopsy Blood Glucose - metabolism Carbohydrate Metabolism Case-Control Studies Diabetes Female Gastric Bypass - adverse effects Gender Glucose Glucose - pharmacokinetics Glucose Transport Proteins, Facilitative - genetics Glucose Transport Proteins, Facilitative - metabolism Humans Insulin - blood Intestinal Absorption Intestines - metabolism Malabsorption Syndromes - genetics Malabsorption Syndromes - metabolism Malabsorption Syndromes - prevention & control Male Middle Aged Obesity Obesity, Morbid - genetics Obesity, Morbid - metabolism Obesity, Morbid - surgery Small intestine Up-Regulation - genetics |
| title | Upregulation of intestinal glucose transporters after Roux‐en‐Y gastric bypass to prevent carbohydrate malabsorption |
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