Upregulation of intestinal glucose transporters after Roux‐en‐Y gastric bypass to prevent carbohydrate malabsorption

Objective To determine the effect of Roux‐en‐Y gastric bypass (RYGB) on the expression of intestinal sweet taste receptors (STRs), glucose transporters (GTs), glucose absorption, and glycemia. Methods Intestinal biopsies were collected for mRNA expression of STR (T1R2) and GTs (SGLT‐1 and GLUT2) from 11 non‐diabetic RYGB, 13 non‐diabetic obese, and 11 healthy subjects, at baseline and following a 30 min small intestinal (SI) glucose infusion (30 g/150 ml water with 3 g 3‐O‐methyl‐d‐glucopyranose (3‐OMG)). Blood glucose, plasma 3‐OMG, and insulin were measured for 270 min. Results In RYGB patients, expression of both GTs was ∼2‐fold higher at baseline and after glucose infusion than those of morbidly obese or healthy subjects (P