Light chain deposition disease without glomerular proteinuria: a diagnostic challenge for the nephrologist

Light chain deposition disease without glomerular proteinuria: a diagnostic challenge for the nephrologist

Renal involvement in light chain (LC) deposition disease (LCDD) is typically characterized by nodular glomerulosclerosis and nephrotic range proteinuria. Rare cases of LCDD without glomerular symptoms have been reported, but clinical and pathological characteristics of this entity remain poorly desc...

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Veröffentlicht in:Nephrology, dialysis, transplantation dialysis, transplantation, 2014-10, Vol.29 (10), p.1894-1902
Hauptverfasser: Sicard, Antoine, Karras, Alexandre, Goujon, Jean-Michel, Sirac, Christophe, Bender, Sébastien, Labatut, Delphine, Callard, Patrice, Sarkozy, Clémentine, Essig, Marie, Vanhille, Philippe, Provot, François, Nony, Alain, Nochy, Dominique, Ronco, Pierre, Bridoux, Frank, Touchard, Guy
Format: Artikel
Sprache:eng
Schlagworte:
Aged
Aged, 80 and over
Amino Acid Sequence
Combined Modality Therapy
Diagnosis, Differential
Female
Follow-Up Studies
Humans
Immunoglobulin Light Chains
Kidney Diseases - diagnosis
Kidney Diseases - mortality
Kidney Diseases - therapy
Kidney Glomerulus - immunology
Kidney Glomerulus - pathology
Male
Middle Aged
Molecular Sequence Data
Multiple Myeloma - diagnosis
Multiple Myeloma - mortality
Multiple Myeloma - therapy
Paraproteinemias - diagnosis
Paraproteinemias - mortality
Paraproteinemias - therapy
Prognosis
Proteinuria - diagnosis
Retrospective Studies
Sequence Homology, Amino Acid
Survival Rate
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Zusammenfassung:Renal involvement in light chain (LC) deposition disease (LCDD) is typically characterized by nodular glomerulosclerosis and nephrotic range proteinuria. Rare cases of LCDD without glomerular symptoms have been reported, but clinical and pathological characteristics of this entity remain poorly described. This multi-centre retrospective study included 14 patients with biopsy-proven renal LCDD and proteinuria
ISSN:0931-0509
1460-2385
DOI:10.1093/ndt/gfu045