A Gender Based Analysis of Predictors of All Cause Death After Transcatheter Aortic Valve Implantation

The impact of gender-related pathophysiologic features of severe aortic stenosis on transcatheter aortic valve implantation (TAVI) outcomes remains to be determined, as does the consistency of predictors of mortality between the genders. All consecutive patients who underwent TAVI at 6 institutions...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The American journal of cardiology 2014-10, Vol.114 (8), p.1269-1274
Hauptverfasser:	Conrotto, Federico, MD, D'Ascenzo, Fabrizio, MD, Salizzoni, Stefano, MD, Presbitero, Patrizia, MD, Agostoni, Pierfrancesco, MD, PhD, Tamburino, Corrado, MD, PhD, Tarantini, Giuseppe, MD, PhD, Bedogni, Francesco, MD, Nijhoff, Freek, MD, Gasparetto, Valeria, MD, Napodano, Massimo, MD, Ferrante, Giuseppe, MD, Rossi, Marco Luciano, MD, Stella, Pieter, MD, PhD, Brambilla, Nedy, MD, Barbanti, Marco, MD, Giordana, Francesca, MD, Grasso, Costanza, MD, Biondi Zoccai, Giuseppe, MD, Moretti, Claudio, MD, D'Amico, Maurizio, MD, Rinaldi, Mauro, MD, Gaita, Fiorenzo, MD, Marra, Sebastiano, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Aortic Valve Stenosis - mortality Aortic Valve Stenosis - surgery Cardiac Catheterization Cardiology Cardiovascular Cause of Death - trends Confidence intervals Female Follow-Up Studies Gender Heart attacks Heart Valve Prosthesis Implantation - methods Humans Incidence Italy - epidemiology Male Medical imaging Mortality Netherlands - epidemiology Postoperative Complications - epidemiology Prognosis Retrospective Studies Risk Assessment - methods Sex Distribution Sex Factors Stroke Studies Survival Rate - trends Time Factors Tomography Variables Women
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The impact of gender-related pathophysiologic features of severe aortic stenosis on transcatheter aortic valve implantation (TAVI) outcomes remains to be determined, as does the consistency of predictors of mortality between the genders. All consecutive patients who underwent TAVI at 6 institutions were enrolled in this study and stratified according to gender. Midterm all-cause mortality was the primary end point, with events at 30 days and at midterm as secondary end points. All events were adjudicated according to Valve Academic Research Consortium definitions. Eight hundred thirty-six patients were enrolled, 464 (55.5%) of whom were female. At midterm follow-up (median 365 days, interquartile range 100 to 516) women had similar rates of all-cause mortality compared with men (18.1% vs 22.6%, p = 0.11) and similar incidence of myocardial infarction and cerebrovascular accident. Gender did not affect mortality also on multivariate analysis. Among clinical and procedural features, glomerular filtration rate 50 mm Hg (HR 2.26, 95% CI 1.26 to 4.02) independently predicted mortality in women, while insulin-treated diabetes (HR 3.45, 95% CI 1.47 to 8.09), previous stroke (HR 3.42, 95% CI 1.43 to 8.18), and an ejection fraction
ISSN:	0002-9149 1879-1913
DOI:	10.1016/j.amjcard.2014.07.053