Risk of Dementia Among Patients With Asthma: A Nationwide Longitudinal Study

Abstract Background Previous studies have suggested an association between asthma and dementia, but the results are still inconsistent. Methods Using the Taiwan National Health Insurance Database, we enrolled 11,030 participants aged more than 45 years with asthma and 44,120 (1:4) age-/sex-matched c...

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Veröffentlicht in:Journal of the American Medical Directors Association 2014-10, Vol.15 (10), p.763-767
Hauptverfasser: Chen, Mu-Hong, MD, Li, Cheng-Ta, MD, PhD, Tsai, Chia-Fen, MD, Lin, Wei-Chen, MD, Chang, Wen-Han, MSc, Chen, Tzeng-Ji, MD, PhD, Pan, Tai-Long, PhD, Su, Tung-Ping, MD, Bai, Ya-Mei, MD, PhD
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Sprache:eng
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Zusammenfassung:Abstract Background Previous studies have suggested an association between asthma and dementia, but the results are still inconsistent. Methods Using the Taiwan National Health Insurance Database, we enrolled 11,030 participants aged more than 45 years with asthma and 44,120 (1:4) age-/sex-matched controls between 1998 and 2008, and followed them to the end of 2011. Cases of any dementia or Alzheimer's disease that developed during the follow-up period were identified. Results Asthma was associated with an increased risk of developing any dementia [hazard ratio (HR): 2.17, 95% confidence interval (CI): 1.87–2.52] and Alzheimer's disease (HR: 2.62, 95% CI: 1.71–4.02). Stratified by age, both asthma in midlife (>45 years and
ISSN:1525-8610
1538-9375
DOI:10.1016/j.jamda.2014.06.003