Deep, Dark Secrets of Melatonin in Animal Evolution

Tosches et al. show that melatonin signaling regulates circadian swimming in annelid worms by rhythmically activating cholinergic neurons. This suggests an evolutionary connection between melatonin signaling in invertebrates and sleep regulation in vertebrates. Tosches et al. show that melatonin sig...

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Veröffentlicht in:	Cell 2014-09, Vol.159 (1), p.9-10
Hauptverfasser:	Schippers, Klaske J., Nichols, Scott A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Melatonin - metabolism Photoreceptor Cells, Invertebrate - metabolism Polychaeta - physiology
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Tosches et al. show that melatonin signaling regulates circadian swimming in annelid worms by rhythmically activating cholinergic neurons. This suggests an evolutionary connection between melatonin signaling in invertebrates and sleep regulation in vertebrates. Tosches et al. show that melatonin signaling regulates circadian swimming in annelid worms by rhythmically activating cholinergic neurons. This suggests an evolutionary connection between melatonin signaling in invertebrates and sleep regulation in vertebrates.
ISSN:	0092-8674 1097-4172
DOI:	10.1016/j.cell.2014.09.004