Antiviral and Immunological Activity of a New Pavine Alkaloid (-)-Thalimonine Isolated from Thalictrum simplex

A pavine alkaloid (‐)‐thalimonine, at a nontoxic concentration range between 0.1 and 100 μM was investigated for antiviral and immunological activity. The alkaloid irreversibly inhibited the replication of herpes simplex virus type 1 (HSV‐1) in MDBK cells with no effect on free virions. The (‐)‐thal...

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Veröffentlicht in:	Phytotherapy research 1996-08, Vol.10 (5), p.414-417
Hauptverfasser:	Varadinova, T. L., Shishkov, S. A., Ivanovska, N. D., Velcheva, M. P., Danghaaghin, Selenghe, Samadanghiin, Zhavzhan, Yansanghiin, Zhamyansan
Format:	Artikel
Sprache:	eng
Schlagworte:	(-)-thalimonine alkaloid Biological and medical sciences General pharmacology herpes simplex virus Medical sciences mitogen-induced proliferation Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments
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Zusammenfassung:	A pavine alkaloid (‐)‐thalimonine, at a nontoxic concentration range between 0.1 and 100 μM was investigated for antiviral and immunological activity. The alkaloid irreversibly inhibited the replication of herpes simplex virus type 1 (HSV‐1) in MDBK cells with no effect on free virions. The (‐)‐thalimonine enhanced the proliferation induced by T‐cell mitogens (PHA, ConA) at lower concentrations and suppressed the action of B‐cell mitogen (LPS) in vitro. Splenic cells from mice pretreated with (‐)‐thalimonine had an elevated response to PHA and a lowered response to LPS.
ISSN:	0951-418X 1099-1573
DOI:	10.1002/(SICI)1099-1573(199608)10:5<414::AID-PTR876>3.0.CO;2-5