Planar Cell Polarity: The Importance of Getting It Backwards

The core and Fat–Dachsous signaling systems locally align planar cell polarities in Drosophila epithelia. Three recent papers address how coupling between these systems can be altered and reversed by the products of the gene prickle. The core and Fat–Dachsous signaling systems locally align planar cell polarities in Drosophila epithelia. Three recent papers address how coupling between these systems can be altered and reversed by the products of the gene prickle.