Facile construction of three contiguous stereogenic centers via dynamic kinetic resolution in asymmetric transfer hydrogenation of quinolines

Facile construction of three contiguous stereogenic centers via dynamic kinetic resolution in asymmetric transfer hydrogenation of quinolines

An efficient and facile route to chiral tetrahydroquinolines with three contiguous stereogenic centers via a dynamic kinetic resolution process has been successfully developed by using chiral phosphoric acid as catalyst and Hantzsch ester as the hydrogen source with up to 89% ee.

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Bibliographische Detailangaben
Veröffentlicht in:Chemical communications (Cambridge, England) England), 2014-01, Vol.50 (83), p.12526-12529
Hauptverfasser: Chen, Mu-Wang, Cai, Xian-Feng, Chen, Zhang-Pei, Shi, Lei, Zhou, Yong-Gui
Format: Artikel
Sprache:eng
Schlagworte:
Catalysis
Crystallography, X-Ray
Hydrogen - chemistry
Hydrogenation
Kinetics
Models, Molecular
Phosphoric Acids - chemistry
Quinolines - chemical synthesis
Quinolines - chemistry
Stereoisomerism
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Beschreibung
Zusammenfassung:An efficient and facile route to chiral tetrahydroquinolines with three contiguous stereogenic centers via a dynamic kinetic resolution process has been successfully developed by using chiral phosphoric acid as catalyst and Hantzsch ester as the hydrogen source with up to 89% ee.
ISSN:1359-7345
1364-548X
DOI:10.1039/c4cc06060a