Unusual anthelminthic oxazoles from a marine sponge

Two heterocycles, bengazole A and bengazole B, have been isolated from a Jaspidae Fiji sponge. These compounds contain bis(oxazole) rings, which is an uncommon natural product structural feature. They exhibit anthelminthic activity, and they fragment on standing to lactone 7 and mono(oxazole) 8, whi...

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Veröffentlicht in:Journal of the American Chemical Society 1988-03, Vol.110 (5), p.1598-1602
Hauptverfasser: Adamczeski, Madeline, Quinoa, Emilio, Crews, Phillip
Format: Artikel
Sprache:eng
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Zusammenfassung:Two heterocycles, bengazole A and bengazole B, have been isolated from a Jaspidae Fiji sponge. These compounds contain bis(oxazole) rings, which is an uncommon natural product structural feature. They exhibit anthelminthic activity, and they fragment on standing to lactone 7 and mono(oxazole) 8, which are devoid of anthelminthic activity but exhibit antimicrobial action.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja00213a037