Significance of clinical and biologic features in Stage 3 neuroblastoma: A report from the International Neuroblastoma Risk Group project

Background International Neuroblastoma Staging System (INSS) Stage 3 neuroblastoma is a heterogeneous disease. Data from the International Neuroblastoma Risk Group (INRG) database were analyzed to define patient and tumor characteristics predictive of outcome. Procedure Of 8,800 patients in the INRG database, 1,483 with INSS Stage 3 neuroblastoma and complete follow‐up data were analyzed. Secondary analysis was performed in 1,013 patients (68%) with MYCN‐non‐amplified (NA) tumors. Significant prognostic factors were identified via log‐rank test comparisons of survival curves. Multivariable Cox proportional hazards regression model was used to identify factors independently predictive of event‐free survival (EFS). Results Age at diagnosis (P