5q- in a case of chronic myelogenous leukemia relapsed after allogeneic bone marrow transplantation
Centro Trapianti di Midollo, Ospedale Maggiore IRCCS, Milano, Italy. Clonal chromosome and/or hematological abnormalities typically observed in myelodysplastic syndromes (MDS) have been described with increased frequency after autologous bone marrow transplantation (BMT) for lymphoma. We report the...
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Veröffentlicht in: | Haematologica (Roma) 1995-09, Vol.80 (5), p.437-439 |
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Zusammenfassung: | Centro Trapianti di Midollo, Ospedale Maggiore IRCCS, Milano, Italy.
Clonal chromosome and/or hematological abnormalities typically observed in myelodysplastic syndromes (MDS) have been described with increased frequency after autologous bone marrow transplantation (BMT) for lymphoma. We report the case of a woman with chronic myelogenous leukemia (CML) allografted with her HLA-identical sibling who, 5 years after the transplant and under immunosuppressive treatment for chronic graft host disease (GVHD), suffered a cytogenetic relapse associated with a 5q- deletion in the host metaphases. These findings suggest that myelodysplastic changes, possibly related to the chemo-radiotherapy conditioning regimen, may also present after allogeneic BMT. |
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ISSN: | 0390-6078 1592-8721 |