SYNTHESIS, CHARACTERIZATION AND ANTI-INFLAMMATORY ACTIVITY OF NOVEL N-SUBSTITUTED-5-OXA-IMIDAZOLE

Various substituted 2-(2'-phenyl-4'-p-dimethylaminobenzylidenyl imidazolin-5'-one)-6-fluoro-7-substituted (1,3) benzothiazoles and 2-(2'-phenyl-4'-o-hydroxy benzylidenyl-5'oxo imidazolin-1-yl amino) -6-fluoro-7-substituted (1,3) benzothiazoles containing different functional groups have been synthesized by treating substituted 2-aminobenzothiazoles with oxozolone in presence of dry pyrirdine. The identity of compounds were confirmed on the basis of their spectral (UV-Visible, IR, super( 1)H NMR and Mass) data. Further, they have been screened for their antimicrobial, antiinflammatory, anticonvulsant and anthelmintic activities.